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- W2334130133 endingPage "52" @default.
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- W2334130133 abstract "Design of small-molecule inhibitors (MDM2 inhibitors) to block the MDM2-p53 protein-protein interaction has been pursued as a new cancer therapeutic strategy. In recent years, potent, selective, and efficacious MDM2 inhibitors have been successfully obtained and seven such compounds have been advanced into early phase clinical trials for the treatment of human cancers. Here, we review the design, synthesis, properties, preclinical, and clinical studies of these clinical-stage MDM2 inhibitors." @default.
- W2334130133 created "2016-06-24" @default.
- W2334130133 creator A5012392120 @default.
- W2334130133 creator A5013707598 @default.
- W2334130133 creator A5073754378 @default.
- W2334130133 creator A5082256258 @default.
- W2334130133 date "2015-02-12" @default.
- W2334130133 modified "2023-10-17" @default.
- W2334130133 title "Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment." @default.
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- W2334130133 doi "https://doi.org/10.1021/jm501092z" @default.
- W2334130133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4329994" @default.
- W2334130133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25396320" @default.
- W2334130133 hasPublicationYear "2015" @default.
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