Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334133604> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2334133604 endingPage "393" @default.
- W2334133604 startingPage "383" @default.
- W2334133604 abstract "In human umbilical vein endothelial cells, treatment with tumor necrosis factor (TNF) -α stimulated the production of cellassociated interleukin (IL) -1α. Combined treatment of human umbilical vein endothelial cells with TNF-α and the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed the TNF-α-induced IL-1α production. However, concentrations of 6-keto-prostaglandin F1α in the conditioned medium were increased to a greater extent by combined treatment with TNF-α and TPA than by single treatment with TNF-α or TPA. Pretreatment with TPA for 15 min was enough to suppress the TNF-α-induced IL-1α production. Pretreatment for 15 min with other PKC activators such as aplysiatoxin (AT) or teleocidin (TC), also inhibited the TNF-α-induced IL-1α production. Stimulation of cell-associated IL-1α production by IL-1β or lipopolysaccharide (LPS) was also inhibited by treatment with the PKC activator TPA, AT or TC. However, treatment with the protein kinase inhibitor H-7 did not block the inhibitory effect of TPA, AT or TC on the cellassociated IL-1α production stimulated by TNF-α, IL-1β or LPS, although the PKC activator induced stimulation of 6-keto-prostaglandin F1α production was counteracted by H-7 treatment. These findings indicate that the production of cell-associated IL-1α stimulat-ed by TNF-α, IL-1β or LPS is inhibited by these PKC activators, but the inhibition by such PKC activators of IL-1α production is not due to PKC-dependent mechanism.To further confirm this notion, effects of these drugs on IL-1 production by other cells were examined. In human pulmonary artery endothelial cells, these PKC activators inhibited cell-associated IL-1α production stimulated by TNF-α, IL-1β or LPS, and this inhibitory effect was not counteracted by the PKC inhibitor H-7 or staurosporine. In contrast, in human epithelial cell line NCI-H292, these PKC activators further enhanced LPS-induced IL-1α production. In addition, IL-1β production by human dermal fibroblasts and human promyelocytic leukemia cell line HL-60 stimulated by LPS or TNF-α was enhanced by these PKC activators. These results suggest that the suppression of IL-1α production by these PKC activators is a specific event to vascular endothelial cells." @default.
- W2334133604 created "2016-06-24" @default.
- W2334133604 creator A5047910903 @default.
- W2334133604 date "1996-01-01" @default.
- W2334133604 modified "2023-09-26" @default.
- W2334133604 title "Suppression of IL-1.ALPHA. production by PKC activators in human umbilical vein endothelial cells." @default.
- W2334133604 doi "https://doi.org/10.2492/jsir1981.16.383" @default.
- W2334133604 hasPublicationYear "1996" @default.
- W2334133604 type Work @default.
- W2334133604 sameAs 2334133604 @default.
- W2334133604 citedByCount "0" @default.
- W2334133604 crossrefType "journal-article" @default.
- W2334133604 hasAuthorship W2334133604A5047910903 @default.
- W2334133604 hasBestOaLocation W23341336041 @default.
- W2334133604 hasConcept C123012128 @default.
- W2334133604 hasConcept C126322002 @default.
- W2334133604 hasConcept C134018914 @default.
- W2334133604 hasConcept C170493617 @default.
- W2334133604 hasConcept C17991360 @default.
- W2334133604 hasConcept C184235292 @default.
- W2334133604 hasConcept C185592680 @default.
- W2334133604 hasConcept C195794163 @default.
- W2334133604 hasConcept C202751555 @default.
- W2334133604 hasConcept C24998067 @default.
- W2334133604 hasConcept C2777411675 @default.
- W2334133604 hasConcept C2777956040 @default.
- W2334133604 hasConcept C2778690821 @default.
- W2334133604 hasConcept C2778754761 @default.
- W2334133604 hasConcept C2909761558 @default.
- W2334133604 hasConcept C55493867 @default.
- W2334133604 hasConcept C71924100 @default.
- W2334133604 hasConcept C88045685 @default.
- W2334133604 hasConceptScore W2334133604C123012128 @default.
- W2334133604 hasConceptScore W2334133604C126322002 @default.
- W2334133604 hasConceptScore W2334133604C134018914 @default.
- W2334133604 hasConceptScore W2334133604C170493617 @default.
- W2334133604 hasConceptScore W2334133604C17991360 @default.
- W2334133604 hasConceptScore W2334133604C184235292 @default.
- W2334133604 hasConceptScore W2334133604C185592680 @default.
- W2334133604 hasConceptScore W2334133604C195794163 @default.
- W2334133604 hasConceptScore W2334133604C202751555 @default.
- W2334133604 hasConceptScore W2334133604C24998067 @default.
- W2334133604 hasConceptScore W2334133604C2777411675 @default.
- W2334133604 hasConceptScore W2334133604C2777956040 @default.
- W2334133604 hasConceptScore W2334133604C2778690821 @default.
- W2334133604 hasConceptScore W2334133604C2778754761 @default.
- W2334133604 hasConceptScore W2334133604C2909761558 @default.
- W2334133604 hasConceptScore W2334133604C55493867 @default.
- W2334133604 hasConceptScore W2334133604C71924100 @default.
- W2334133604 hasConceptScore W2334133604C88045685 @default.
- W2334133604 hasIssue "6" @default.
- W2334133604 hasLocation W23341336041 @default.
- W2334133604 hasOpenAccess W2334133604 @default.
- W2334133604 hasPrimaryLocation W23341336041 @default.
- W2334133604 hasRelatedWork W1599732572 @default.
- W2334133604 hasRelatedWork W1660988713 @default.
- W2334133604 hasRelatedWork W1968020384 @default.
- W2334133604 hasRelatedWork W1987000956 @default.
- W2334133604 hasRelatedWork W2034385224 @default.
- W2334133604 hasRelatedWork W2040440085 @default.
- W2334133604 hasRelatedWork W2067893925 @default.
- W2334133604 hasRelatedWork W2074100151 @default.
- W2334133604 hasRelatedWork W2074449321 @default.
- W2334133604 hasRelatedWork W2078418435 @default.
- W2334133604 hasRelatedWork W2088231486 @default.
- W2334133604 hasRelatedWork W2092626261 @default.
- W2334133604 hasRelatedWork W2129505596 @default.
- W2334133604 hasRelatedWork W2147355809 @default.
- W2334133604 hasRelatedWork W2147721774 @default.
- W2334133604 hasRelatedWork W2163641593 @default.
- W2334133604 hasRelatedWork W2248477382 @default.
- W2334133604 hasRelatedWork W2404489603 @default.
- W2334133604 hasRelatedWork W2408626480 @default.
- W2334133604 hasRelatedWork W3032079815 @default.
- W2334133604 hasVolume "16" @default.
- W2334133604 isParatext "false" @default.
- W2334133604 isRetracted "false" @default.
- W2334133604 magId "2334133604" @default.
- W2334133604 workType "article" @default.