Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334138724> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2334138724 abstract "Angiogenesis, the formation of new blood vessels from pre-existing ones, is vital for tumor growth and spread. A better understanding of angiogenic processes, particularly cell-cell adhesion, is required for the development of effective anti-angiogenic drugs. Claudin-14 (Cldn14) is a component of Tight Junctions (TJ) and its function in angiogenesis is not yet known. Other TJ molecules such as JAMs are known to be involved in angiogenesis; for example, we have identified a novel dosage-dependent role for JAM-B in the regulation of angiogenesis in the context of trisomy of human chromosome 21 (Hsa21) genes (Reynolds et al. Nature 2010); Cldn14 is also present on Hsa21. Therefore we hypothesise that Cldn14 may also play a role in the regulation of angiogenesis. Here we show that depletion of Cldn14 enhances VEGF-stimulated angiogenesis in the ex vivo aortic ring assay and increases primary mouse lung endothelial cell proliferation via changes in downstream signalling. Viable Cldn14 knockout mice exhibit normal vasculature in unchallenged organs, suggesting that the effect may be specific to pathological states. These data reveal novel regulatory roles for Cldn14 and future work will characterise further the functions of Cldn14 in angiogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3479. doi:10.1158/1538-7445.AM2011-3479" @default.
- W2334138724 created "2016-06-24" @default.
- W2334138724 creator A5008214735 @default.
- W2334138724 creator A5024660419 @default.
- W2334138724 creator A5026920265 @default.
- W2334138724 creator A5079038299 @default.
- W2334138724 date "2011-04-15" @default.
- W2334138724 modified "2023-09-27" @default.
- W2334138724 title "Abstract 3479: Claudin-14: A novel regulator of angiogenesis" @default.
- W2334138724 doi "https://doi.org/10.1158/1538-7445.am2011-3479" @default.
- W2334138724 hasPublicationYear "2011" @default.
- W2334138724 type Work @default.
- W2334138724 sameAs 2334138724 @default.
- W2334138724 citedByCount "0" @default.
- W2334138724 crossrefType "proceedings-article" @default.
- W2334138724 hasAuthorship W2334138724A5008214735 @default.
- W2334138724 hasAuthorship W2334138724A5024660419 @default.
- W2334138724 hasAuthorship W2334138724A5026920265 @default.
- W2334138724 hasAuthorship W2334138724A5079038299 @default.
- W2334138724 hasConcept C123012128 @default.
- W2334138724 hasConcept C151730666 @default.
- W2334138724 hasConcept C177779419 @default.
- W2334138724 hasConcept C202751555 @default.
- W2334138724 hasConcept C203014093 @default.
- W2334138724 hasConcept C2778271429 @default.
- W2334138724 hasConcept C2779343474 @default.
- W2334138724 hasConcept C2780394083 @default.
- W2334138724 hasConcept C502942594 @default.
- W2334138724 hasConcept C51872919 @default.
- W2334138724 hasConcept C54355233 @default.
- W2334138724 hasConcept C71924100 @default.
- W2334138724 hasConcept C86803240 @default.
- W2334138724 hasConcept C95444343 @default.
- W2334138724 hasConceptScore W2334138724C123012128 @default.
- W2334138724 hasConceptScore W2334138724C151730666 @default.
- W2334138724 hasConceptScore W2334138724C177779419 @default.
- W2334138724 hasConceptScore W2334138724C202751555 @default.
- W2334138724 hasConceptScore W2334138724C203014093 @default.
- W2334138724 hasConceptScore W2334138724C2778271429 @default.
- W2334138724 hasConceptScore W2334138724C2779343474 @default.
- W2334138724 hasConceptScore W2334138724C2780394083 @default.
- W2334138724 hasConceptScore W2334138724C502942594 @default.
- W2334138724 hasConceptScore W2334138724C51872919 @default.
- W2334138724 hasConceptScore W2334138724C54355233 @default.
- W2334138724 hasConceptScore W2334138724C71924100 @default.
- W2334138724 hasConceptScore W2334138724C86803240 @default.
- W2334138724 hasConceptScore W2334138724C95444343 @default.
- W2334138724 hasLocation W23341387241 @default.
- W2334138724 hasOpenAccess W2334138724 @default.
- W2334138724 hasPrimaryLocation W23341387241 @default.
- W2334138724 hasRelatedWork W1547151091 @default.
- W2334138724 hasRelatedWork W1976888102 @default.
- W2334138724 hasRelatedWork W2014185976 @default.
- W2334138724 hasRelatedWork W2040176373 @default.
- W2334138724 hasRelatedWork W2057360406 @default.
- W2334138724 hasRelatedWork W2059314682 @default.
- W2334138724 hasRelatedWork W2150537620 @default.
- W2334138724 hasRelatedWork W2261612490 @default.
- W2334138724 hasRelatedWork W2564120513 @default.
- W2334138724 hasRelatedWork W289959598 @default.
- W2334138724 hasRelatedWork W2900784569 @default.
- W2334138724 hasRelatedWork W2963405250 @default.
- W2334138724 hasRelatedWork W3000382063 @default.
- W2334138724 hasRelatedWork W3025051055 @default.
- W2334138724 hasRelatedWork W3034541330 @default.
- W2334138724 hasRelatedWork W3094816479 @default.
- W2334138724 hasRelatedWork W3151410902 @default.
- W2334138724 hasRelatedWork W47603305 @default.
- W2334138724 hasRelatedWork W77241945 @default.
- W2334138724 hasRelatedWork W1497923198 @default.
- W2334138724 isParatext "false" @default.
- W2334138724 isRetracted "false" @default.
- W2334138724 magId "2334138724" @default.
- W2334138724 workType "article" @default.