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- W2334175488 abstract "Electron affinity, as measured by the one-electron reduction potential $E_{7}^{1}$ , is the major factor influencing sensitizing efficiency in vitro. CB 1954 is thought to be a monofunctional alkylating agent, which has an electron affinity ( $E_{7}^{1}$ = -385 mV) similar to misonidazole. However, the ability of this compound to sensitize hypoxic cells is considerably greater than that of misonidazole; e.g., 0.2 mM CB 1954 gives an enhancement ratio of 2.2 compared to 1.5 for the same concentration of misonidazole. 2-Phenyl-4(5)-amino-5(4)-carboxamide (phenyl-AIC) can protect against the cytotoxic action of CB 1954. Further, when cells were irradiated in the presence of CB 1954 and phenyl-AIC, sensitization was reduced to a level similar to that seen for misonidazole, indicating that phenyl-AIC can protect against part of the sensitization caused by CB 1954. The additional sensitization seen with CB 1954 may be associated with the cytotoxic activity of this compoun..." @default.
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- W2334175488 date "1981-12-01" @default.
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- W2334175488 title "Radiosensitizing and Cytotoxicity Studies with CB 1954 (2,4-Dinitro-5-Aziridinylbenzamide)" @default.
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- W2334175488 doi "https://doi.org/10.2307/3575639" @default.
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