FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334193310> ?p ?o ?g. }

• W2334193310 endingPage "48" @default.
• W2334193310 startingPage "43" @default.
• W2334193310 abstract "Stimulatory and inhibitory receptor signaling (cosignaling) on T cells is a critical component of T-cell responses that mediate graft rejection. The blockade of cosignaling pathways is an attractive strategy for preventing allogeneic T-cell responses. Here, we review the new studies that provide critical insight into the well studied CD28-CTLA-4 and CD40-CD40L cosignaling pathways, as well as the identification of novel cosignaling receptors that play a role in allogeneic T-cell responses.Recently, it has been appreciated that the CD28-CTLA-4 pathway has unique roles on specific T-cell subsets, particularly on forkhead box P3 (FoxP3)+ regulatory T cell (Treg) and T helper 17 (Th17) cells. New insight has been provided into the mechanism by which CD40-CD154 blockade elicits FoxP3+ Treg conversion and memory T cells elicit CD40-independent alloantibody responses. Finally, several novel cosignaling pathways have been demonstrated to be important to graft-specific T cells, including CD160, signaling lymphocytic activation molecule family member 2B4, T-cell Ig mucin 4, and the Notch receptor.Recent work has provided more granular understanding of the CD28-CTLA-4 and CD40-CD154 pathways on T-cell subsets, and provided important insight into the generation and maintenance of FoxP3+ Treg. This information, as well as the characterization of novel transplantation-relevant cosignaling pathways, has implications for the modulation of alloreactive T-cell responses." @default.
• W2334193310 created "2016-06-24" @default.
• W2334193310 creator A5072841589 @default.
• W2334193310 creator A5087476769 @default.
• W2334193310 date "2015-02-01" @default.
• W2334193310 modified "2023-09-28" @default.
• W2334193310 title "New insights into T-cell cosignaling in allograft rejection and survival" @default.
• W2334193310 cites W1513033691 @default.
• W2334193310 cites W1520683019 @default.
• W2334193310 cites W1590311841 @default.
• W2334193310 cites W1616440767 @default.
• W2334193310 cites W1680805597 @default.
• W2334193310 cites W1907829837 @default.
• W2334193310 cites W1982505108 @default.
• W2334193310 cites W2001101603 @default.
• W2334193310 cites W2011957759 @default.
• W2334193310 cites W2039522510 @default.
• W2334193310 cites W2041152507 @default.
• W2334193310 cites W2057648030 @default.
• W2334193310 cites W2059232583 @default.
• W2334193310 cites W2060445820 @default.
• W2334193310 cites W2061071534 @default.
• W2334193310 cites W2061440208 @default.
• W2334193310 cites W2082040247 @default.
• W2334193310 cites W2091354749 @default.
• W2334193310 cites W2105787447 @default.
• W2334193310 cites W2108758471 @default.
• W2334193310 cites W2109942683 @default.
• W2334193310 cites W2112899625 @default.
• W2334193310 cites W2125758525 @default.
• W2334193310 cites W2125956827 @default.
• W2334193310 cites W2126945681 @default.
• W2334193310 cites W2130473166 @default.
• W2334193310 cites W2140041178 @default.
• W2334193310 cites W2145562912 @default.
• W2334193310 cites W2149142511 @default.
• W2334193310 cites W2155723577 @default.
• W2334193310 cites W2161101031 @default.
• W2334193310 cites W2162540156 @default.
• W2334193310 cites W2167010530 @default.
• W2334193310 cites W2167385707 @default.
• W2334193310 cites W2169800587 @default.
• W2334193310 cites W2172223853 @default.
• W2334193310 cites W4242872472 @default.
• W2334193310 doi "https://doi.org/10.1097/mot.0000000000000151" @default.
• W2334193310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4365925" @default.
• W2334193310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25563991" @default.
• W2334193310 hasPublicationYear "2015" @default.
• W2334193310 type Work @default.
• W2334193310 sameAs 2334193310 @default.
• W2334193310 citedByCount "8" @default.
• W2334193310 countsByYear W23341933102015 @default.
• W2334193310 countsByYear W23341933102016 @default.
• W2334193310 countsByYear W23341933102017 @default.
• W2334193310 countsByYear W23341933102019 @default.
• W2334193310 countsByYear W23341933102021 @default.
• W2334193310 countsByYear W23341933102022 @default.
• W2334193310 crossrefType "journal-article" @default.
• W2334193310 hasAuthorship W2334193310A5072841589 @default.
• W2334193310 hasAuthorship W2334193310A5087476769 @default.
• W2334193310 hasBestOaLocation W23341933102 @default.
• W2334193310 hasConcept C148125776 @default.
• W2334193310 hasConcept C154317977 @default.
• W2334193310 hasConcept C202751555 @default.
• W2334193310 hasConcept C203014093 @default.
• W2334193310 hasConcept C21705690 @default.
• W2334193310 hasConcept C2776090121 @default.
• W2334193310 hasConcept C2779234475 @default.
• W2334193310 hasConcept C2779727006 @default.
• W2334193310 hasConcept C39347974 @default.
• W2334193310 hasConcept C502942594 @default.
• W2334193310 hasConcept C54355233 @default.
• W2334193310 hasConcept C62478195 @default.
• W2334193310 hasConcept C86803240 @default.
• W2334193310 hasConcept C8891405 @default.
• W2334193310 hasConcept C95444343 @default.
• W2334193310 hasConceptScore W2334193310C148125776 @default.
• W2334193310 hasConceptScore W2334193310C154317977 @default.
• W2334193310 hasConceptScore W2334193310C202751555 @default.
• W2334193310 hasConceptScore W2334193310C203014093 @default.
• W2334193310 hasConceptScore W2334193310C21705690 @default.
• W2334193310 hasConceptScore W2334193310C2776090121 @default.
• W2334193310 hasConceptScore W2334193310C2779234475 @default.
• W2334193310 hasConceptScore W2334193310C2779727006 @default.
• W2334193310 hasConceptScore W2334193310C39347974 @default.
• W2334193310 hasConceptScore W2334193310C502942594 @default.
• W2334193310 hasConceptScore W2334193310C54355233 @default.
• W2334193310 hasConceptScore W2334193310C62478195 @default.
• W2334193310 hasConceptScore W2334193310C86803240 @default.
• W2334193310 hasConceptScore W2334193310C8891405 @default.
• W2334193310 hasConceptScore W2334193310C95444343 @default.
• W2334193310 hasIssue "1" @default.
• W2334193310 hasLocation W23341933101 @default.
• W2334193310 hasLocation W23341933102 @default.
• W2334193310 hasLocation W23341933103 @default.
• W2334193310 hasLocation W23341933104 @default.
• W2334193310 hasOpenAccess W2334193310 @default.
• W2334193310 hasPrimaryLocation W23341933101 @default.

• next