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- W2334218149 abstract "CEBPG (CCAAT/enhancer binding protein gamma) is one of six known members of the CEBP family of bZIP transcription factors. Gene targeted knock-out of CEBPG transcription factor in mice results in early perinatal death, presumably due to observed emphysematous lung histology and abnormal development of alveolar pneumocytes (Kaisho et al, 1999). In recent studies, we observed that: 1) CEBPG transcript expression in normal human bronchial epithelial cells (NBEC) varies greater than 20-fold among individuals (Mullins et al, 2005), 2) the pattern of CEBPG transcript expression in NBEC is different between lung cancer cases and controls (Blomquist et al, 2009), and 3) transcript expression of a key DNA repair gene, ERCC5 (XPG), is partly regulated by CEBPG in NBEC (Crawford et al, 2007). In this study we hypothesized that variation in CEBPG transcript expression patterns in NBEC may, in part, be due to cis-acting genetic variation. In order to test this hypothesis, Allele-Specific Expression (ASE) was measured at transcribed polymorphic site rs2772 in Exon 2 of CEBPG in NBEC cDNA of fifteen individuals heterozygous at rs2772 using allele-specific competitive PCR. ASE at rs2772 was then assessed for association with genotype at the seven polymorphic sites (rs736682, rs17530479, rs17530508, rs1469084, rs16968029, rs3745968, rs36101103) representing the most common haplotypes in the promoter, intron and 3′-untranslated regions of CEBPG gene. CEBPG rs2772 A allele was expressed, on average, 2.34 fold greater than C allele (p Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4988." @default.
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- W2334218149 date "2010-04-15" @default.
- W2334218149 modified "2023-09-27" @default.
- W2334218149 title "Abstract 4988:Cis-acting genetic variation is associated with altered allele-specific expression of CEBPG transcript in normal human bronchial epithelium" @default.
- W2334218149 doi "https://doi.org/10.1158/1538-7445.am10-4988" @default.
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