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• W2334219097 abstract "Two end-decorated homopolymers, methoxy polyethylene glycol-ferrocene (mPEG-Fc) and poly(N-isopropylacrylamide)-β-cyclodextrin (PNIPAM-β-CD), were further orthogonally self-assembled into stable micelles in aqueous solution by controlling the temperature of the solution via terminal host–guest interactions. Because of the H2O2 cleavable CD/Fc connection and thermoresponsive PNIPAM, an H2O2 and thermo dual-controlled drug release based on this system was also achieved. Interestingly, the cytotoxicity evaluation of mPEG-Fc/PNIPAM-β-CD indicated good biocompatibility. Compared with free doxorubicin, the doxorubicin-loaded supramolecular micelles exhibited equal cellular proliferation inhibition toward A549 cells. This supramolecular complex is thus anticipated to serve as a promising new type of alternative drug-delivery system." @default.
• W2334219097 created "2016-06-24" @default.
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• W2334219097 date "2015-04-21" @default.
• W2334219097 modified "2023-09-24" @default.
• W2334219097 title "Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers" @default.
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• W2334219097 doi "https://doi.org/10.1021/acsmacrolett.5b00171" @default.
• W2334219097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35596290" @default.
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