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- W2334220360 abstract "This article reviews a long-standing hypothesis that metastases might be initiated through the generation of hybrids between primary tumour cells and tumour-infiltrating leucocytes such as macrophages. In this concept the hybrids become metastatic through expression of the leucocyte motility phenotype. A history of the hybrid hypothesis is presented along with recent evidence on how macrophage x tumour cell hybridization could account for some of the most defining characteristics of metastatic cells: aneuploidy, enhanced motility, aberrant glycosylation and, particularly seen in melanoma, phenotypic diversity." @default.
- W2334220360 created "2016-06-24" @default.
- W2334220360 creator A5055718904 @default.
- W2334220360 date "2000-12-01" @default.
- W2334220360 modified "2023-10-08" @default.
- W2334220360 title "Tumour cell hybridization and metastasis revisited" @default.
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- W2334220360 doi "https://doi.org/10.1097/00008390-200012000-00001" @default.
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