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• W2334241120 abstract "Objective: This study aims to elucidate the combined effect of sulfamethoxazole (SMX) and antioxidant selenium (Se) on hematological parameters and antioxidant system in diethylnitrosamine (DEN) induced toxicity in rats. Materials and Methods: Forty two male albino wistar rats were randomly assigned into seven groups of six rats each. Group 1 was control, while groups 2 (DEN control), group 3 (SMX control), group 4 (Se control), group 5 (SMX + Selenium control), group 6 (THR) and group 7 (PRH), received 30mg/kg sulfamethoxazole hydrochloride, 4 mg/ kg sodium selenite orally and single dose of 150 mg/kg DEN i.p. for 22 weeks, respectively. Rats in all seven groups received normal rat chow and drinking water ad libitum. Complete blood count was done using an automatic counter. Results and Discussion: Rats treated with DEN showed severe toxic signs and significant decrease (P <0.05) white blood cell, red blood cell, hemoglobin concentration. However, the mean neutrophils count in the all groups was decreased significantly (P<0.001) except in the animals of group 4. The RBC count of the groups 4 and 6 was significantly higher than that of the animals of groups 2 and 7 (P<0.001). The antioxident activity of enzymes GST, catalase, GPx and SOD in the animals of group 6 were found to be SMX significant increased but a significant decrease (P < 0.001) in the levels of GSH was observed when compared with DEN treated group. However, co-administration of sulfamethoxazole (SMX) and selenium (Se) had a protective effect on the potential carcinogen DEN. Conclusion: Thus it is concluded that oral administration of sulfamethoxazole and selenium increases RBC, Hb concentration, neutrophils and antioxident enzymes in treatment group." @default.
• W2334241120 created "2016-06-24" @default.
• W2334241120 creator A5037968699 @default.
• W2334241120 date "2013-01-01" @default.
• W2334241120 modified "2023-10-05" @default.
• W2334241120 title "The Effect of Sulfamethoxazole and Selenium on Antioxidant Defense System in the Blood of Rats Treated With DEN" @default.
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• W2334241120 doi "https://doi.org/10.9790/3008-0862937" @default.
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