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- W2334244572 abstract "Porphyrin derivatives have applications as photoactive drugs in photodynamic therapy. However, little is known about their interactions with phospholipid membranes at the molecular level. We employed molecular dynamics simulations to model the binding between a series of cationic meso-(N-methyl-4-pyridinium)phenylporphyrins and anionic phosphatidylglycerol lipid bilayers. This was done in the presence of molecular oxygen within the membrane. The ability of various porphyrins to cause photodamage was quantified in terms of their immersion depth and degree of exposition to a higher oxygen concentration inside the membrane. Simulations showed that the photodynamic efficiency could be improved as the number of hydrophobic phenyl substituents attached to the porphyrinic ring increased. In the specific case of porphyrins containing two hydrophobic and two charged substituents, the cis isomer was significantly more efficient than the trans. These results correlate well with previous experimental observations. They highlight the importance of both the total charge and amphiphilicity of the photosensitizer for its performance in photodynamic therapy." @default.
- W2334244572 created "2016-06-24" @default.
- W2334244572 creator A5007458912 @default.
- W2334244572 creator A5055148542 @default.
- W2334244572 creator A5083418342 @default.
- W2334244572 date "2012-11-19" @default.
- W2334244572 modified "2023-09-27" @default.
- W2334244572 title "Photodynamic Efficiency of Cationic <i>meso</i>-Porphyrins at Lipid Bilayers: Insights from Molecular Dynamics Simulations" @default.
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- W2334244572 cites W1919412794 @default.
- W2334244572 cites W1964893456 @default.
- W2334244572 cites W1966078827 @default.
- W2334244572 cites W1975351844 @default.
- W2334244572 cites W1978498560 @default.
- W2334244572 cites W1978924267 @default.
- W2334244572 cites W1980267010 @default.
- W2334244572 cites W1990726694 @default.
- W2334244572 cites W1991794210 @default.
- W2334244572 cites W1995651111 @default.
- W2334244572 cites W1996687357 @default.
- W2334244572 cites W1998708521 @default.
- W2334244572 cites W2000169833 @default.
- W2334244572 cites W2009828713 @default.
- W2334244572 cites W2018551035 @default.
- W2334244572 cites W2019098068 @default.
- W2334244572 cites W2019599427 @default.
- W2334244572 cites W2020942641 @default.
- W2334244572 cites W2022922542 @default.
- W2334244572 cites W2025479210 @default.
- W2334244572 cites W2029667189 @default.
- W2334244572 cites W2033279283 @default.
- W2334244572 cites W2034395659 @default.
- W2334244572 cites W2035687084 @default.
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- W2334244572 cites W2040625080 @default.
- W2334244572 cites W2041638382 @default.
- W2334244572 cites W2051381895 @default.
- W2334244572 cites W2056172163 @default.
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- W2334244572 cites W2144630525 @default.
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- W2334244572 cites W2171268876 @default.
- W2334244572 cites W2174403310 @default.
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- W2334244572 cites W2317871806 @default.
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- W2334244572 doi "https://doi.org/10.1021/jp308179h" @default.
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