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- W2334244908 abstract "Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with complex genetic architectures but overlapping behavioral phenotypes, which suggests common pathway perturbations. Multiple lines of evidence implicate imbalances in excitatory and inhibitory activity (E/I imbalance) as a shared pathophysiological mechanism. Thus, understanding the molecular underpinnings of E/I imbalance may provide essential insight into the etiology of these disorders and may uncover novel targets for future drug discovery. Here, we review key genetic, physiological, neuropathological, functional, and pathway studies that suggest alterations to excitatory/inhibitory circuits are keys to ASD and SCZ pathogenesis." @default.
- W2334244908 created "2016-06-24" @default.
- W2334244908 creator A5071692996 @default.
- W2334244908 creator A5072356141 @default.
- W2334244908 date "2015-03-18" @default.
- W2334244908 modified "2023-10-16" @default.
- W2334244908 title "Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders" @default.
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