Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334257872> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2334257872 endingPage "5844" @default.
- W2334257872 startingPage "5829" @default.
- W2334257872 abstract "Nanoparticle-based pharmaceutical products are currently finding their way onto the market as a popular strategy to improve the therapeutic efficacy of numerous drugs, hereunder medications for a targeted treatment of severe diseases (e.g., cancer). Drug-loaded polymer and lipid nanoparticles are typically produced via solventbased methods and result in colloidal suspensions, which often suffer from physical and chemical instability (e.g., formation of aggregates) resulting in loss of functionality. There are various ways to stabilize such nanoparticlebased formulations including addition of ionic materials to provide electrostatic repulsion or polymer materials forming a steric barrier between the particles. However, for long-term stability often water needs to be removed to obtain a dry product. For this purpose atomization-based techniques such as spray-drying and spray freeze-drying are frequently used to remove water from the nanoparticle suspensions and to form tailored powder products (e.g., nanoembedded microparticles (NEMs)). NEMs provide an excellent vehicle for both stabilization of nanoparticles and delivery of the nanoparticles to their intended site of action. Excipients such as sugars and biocompatible polymers are used to prepare the surrounding, stabilizing matrix. Further, these “Trojan” vehicles are compatible with a wide range of therapeutic molecules, nanocarriers and applications for different routes of administration. The preparation, properties and stability of these NEMs are described in this review and their application and future development are discussed. Keywords: Nanoembedded microparticles, nanoparticles, spray drying, freeze drying, drug delivery, nanomedicine." @default.
- W2334257872 created "2016-06-24" @default.
- W2334257872 creator A5003455183 @default.
- W2334257872 creator A5036843968 @default.
- W2334257872 creator A5037563650 @default.
- W2334257872 creator A5090244511 @default.
- W2334257872 date "2015-11-20" @default.
- W2334257872 modified "2023-10-03" @default.
- W2334257872 title "Nanoembedded Microparticles for Stabilization and Delivery of Drug-Loaded Nanoparticles" @default.
- W2334257872 doi "https://doi.org/10.2174/1381612821666151008124322" @default.
- W2334257872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26446473" @default.
- W2334257872 hasPublicationYear "2015" @default.
- W2334257872 type Work @default.
- W2334257872 sameAs 2334257872 @default.
- W2334257872 citedByCount "30" @default.
- W2334257872 countsByYear W23342578722016 @default.
- W2334257872 countsByYear W23342578722017 @default.
- W2334257872 countsByYear W23342578722018 @default.
- W2334257872 countsByYear W23342578722019 @default.
- W2334257872 countsByYear W23342578722020 @default.
- W2334257872 countsByYear W23342578722021 @default.
- W2334257872 countsByYear W23342578722022 @default.
- W2334257872 countsByYear W23342578722023 @default.
- W2334257872 crossrefType "journal-article" @default.
- W2334257872 hasAuthorship W2334257872A5003455183 @default.
- W2334257872 hasAuthorship W2334257872A5036843968 @default.
- W2334257872 hasAuthorship W2334257872A5037563650 @default.
- W2334257872 hasAuthorship W2334257872A5090244511 @default.
- W2334257872 hasConcept C127413603 @default.
- W2334257872 hasConcept C15083742 @default.
- W2334257872 hasConcept C155672457 @default.
- W2334257872 hasConcept C159985019 @default.
- W2334257872 hasConcept C171250308 @default.
- W2334257872 hasConcept C178790620 @default.
- W2334257872 hasConcept C18150654 @default.
- W2334257872 hasConcept C185592680 @default.
- W2334257872 hasConcept C192562407 @default.
- W2334257872 hasConcept C2777521759 @default.
- W2334257872 hasConcept C2779587474 @default.
- W2334257872 hasConcept C2779820397 @default.
- W2334257872 hasConcept C42360764 @default.
- W2334257872 hasConcept C521977710 @default.
- W2334257872 hasConceptScore W2334257872C127413603 @default.
- W2334257872 hasConceptScore W2334257872C15083742 @default.
- W2334257872 hasConceptScore W2334257872C155672457 @default.
- W2334257872 hasConceptScore W2334257872C159985019 @default.
- W2334257872 hasConceptScore W2334257872C171250308 @default.
- W2334257872 hasConceptScore W2334257872C178790620 @default.
- W2334257872 hasConceptScore W2334257872C18150654 @default.
- W2334257872 hasConceptScore W2334257872C185592680 @default.
- W2334257872 hasConceptScore W2334257872C192562407 @default.
- W2334257872 hasConceptScore W2334257872C2777521759 @default.
- W2334257872 hasConceptScore W2334257872C2779587474 @default.
- W2334257872 hasConceptScore W2334257872C2779820397 @default.
- W2334257872 hasConceptScore W2334257872C42360764 @default.
- W2334257872 hasConceptScore W2334257872C521977710 @default.
- W2334257872 hasIssue "40" @default.
- W2334257872 hasLocation W23342578721 @default.
- W2334257872 hasLocation W23342578722 @default.
- W2334257872 hasOpenAccess W2334257872 @default.
- W2334257872 hasPrimaryLocation W23342578721 @default.
- W2334257872 hasRelatedWork W1595862141 @default.
- W2334257872 hasRelatedWork W2092025079 @default.
- W2334257872 hasRelatedWork W2227393653 @default.
- W2334257872 hasRelatedWork W2790347249 @default.
- W2334257872 hasRelatedWork W2947366936 @default.
- W2334257872 hasRelatedWork W3148284110 @default.
- W2334257872 hasRelatedWork W3190497104 @default.
- W2334257872 hasRelatedWork W4309381012 @default.
- W2334257872 hasRelatedWork W4323058072 @default.
- W2334257872 hasRelatedWork W4384207148 @default.
- W2334257872 hasVolume "21" @default.
- W2334257872 isParatext "false" @default.
- W2334257872 isRetracted "false" @default.
- W2334257872 magId "2334257872" @default.
- W2334257872 workType "article" @default.