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• W2334262022 endingPage "12856" @default.
• W2334262022 startingPage "12841" @default.
• W2334262022 abstract "The reactions of octachlorocyclotetraphosphazene, N4P4Cl8, with N2O2 donor-type aminopodands (1a, 1b, 1g, and 1h) afforded two kinds of derivatives, namely, spiro-ansa-spiro (sas) (2a, 2b, 2g, and 2h) and ansa-spiro-ansa (asa) (3a and 3b) phosphazenes. The partly substituted sas phosphazenes (2a and 2b) reacted with excess pyrrolidine and morpholine in tetrahydrofuran to produce the tetrapyrrolidino (2c and 2d) and morpholino (2e and 2f) derivatives. The reactions of the asa phosphazenes (3a and 3b) with excess pyrrolidine and morpholine produced gem-2-trans-6-dichloropyrrolidinophosphazenes (3c and 3d) and -morpholinophosphazenes (3e and 3f). However, the fully substituted products were not obtained in these solvents. In addition, the expected fully substituted compound was not obtained from the reaction of 3a with excess pyrrolidine by standard or microwave-assisted methods. The reaction of the long-chain starting compound (1g) with N4P4Cl8 gave sas (2g) and the interesting 2,6-ansa-spiro-bicyclo product (bicyclo-2,6-as; 4g), while the reaction of 1h with N4P4Cl8 yielded only sas (2h). The structural investigations of the compounds were verified by elemental analyses, mass spectrometry, Fourier transform infrared, and DEPT, HSQC, HMBC, 1H, 13C, and 31P NMR techniques. The crystal structures of 2b, 3a, 3b, 3e, and 4g were determined by X-ray crystallography. Compounds 2a–2h, 3a–3f, and 4g had two stereogenic P atoms. Compound 3b had one enantiomer according to the Flack parameter, and 3f was a racemic mixture, as shown by chiral high-performance liquid chromatography and chiral-solvating-agent, (R)-(+)-2,2,2-trifluoro-1-(9′-anthryl)ethanol, experiments. Furthermore, compounds 2a, 2c, and 2d exhibited weak antibacterial activity against (G+) bacterium, and 3c and 3d displayed moderate antifungal activity against Candida tropicalis. Gel electrophoresis data demonstrated that 2e, 3c, and 3e promoted the formation of DNA cleavage. The prevention of BamHI digestion by 2a–2f and 3a–3f, except 2b and 2e, disclosed binding with GG nucleotides in DNA." @default.
• W2334262022 created "2016-06-24" @default.
• W2334262022 creator A5002888873 @default.
• W2334262022 creator A5014140383 @default.
• W2334262022 creator A5014288136 @default.
• W2334262022 creator A5022699057 @default.
• W2334262022 creator A5057385398 @default.
• W2334262022 creator A5063163449 @default.
• W2334262022 creator A5065431371 @default.
• W2334262022 creator A5087580930 @default.
• W2334262022 date "2012-11-19" @default.
• W2334262022 modified "2023-09-26" @default.
• W2334262022 title "Phosphorus–Nitrogen Compounds. Part 24. Syntheses, Crystal Structures, Spectroscopic and Stereogenic Properties, Biological Activities, and DNA Interactions of Novel Spiro-ansa-spiro- and Ansa-spiro-ansa-cyclotetraphosphazenes" @default.
• W2334262022 cites W1640405485 @default.
• W2334262022 cites W1968710854 @default.
• W2334262022 cites W1974197974 @default.
• W2334262022 cites W1976733849 @default.
• W2334262022 cites W1978135921 @default.
• W2334262022 cites W1982414593 @default.
• W2334262022 cites W1984172159 @default.
• W2334262022 cites W1984303794 @default.
• W2334262022 cites W1984859155 @default.
• W2334262022 cites W1986095048 @default.
• W2334262022 cites W1988563308 @default.
• W2334262022 cites W1989040098 @default.
• W2334262022 cites W1989834812 @default.
• W2334262022 cites W1990342713 @default.
• W2334262022 cites W1990975162 @default.
• W2334262022 cites W1994753048 @default.
• W2334262022 cites W1997207987 @default.
• W2334262022 cites W1999108026 @default.
• W2334262022 cites W1999686760 @default.
• W2334262022 cites W1999789963 @default.
• W2334262022 cites W2000600910 @default.
• W2334262022 cites W2001199253 @default.
• W2334262022 cites W2004381789 @default.
• W2334262022 cites W2004678346 @default.
• W2334262022 cites W2005818295 @default.
• W2334262022 cites W2007247521 @default.
• W2334262022 cites W2008420583 @default.
• W2334262022 cites W2009215409 @default.
• W2334262022 cites W2014126144 @default.
• W2334262022 cites W2017388862 @default.
• W2334262022 cites W2020446718 @default.
• W2334262022 cites W2021317298 @default.
• W2334262022 cites W2021813629 @default.
• W2334262022 cites W2022827383 @default.
• W2334262022 cites W2025053353 @default.
• W2334262022 cites W2025359976 @default.
• W2334262022 cites W2025413331 @default.
• W2334262022 cites W2026743098 @default.
• W2334262022 cites W2030926433 @default.
• W2334262022 cites W2032086955 @default.
• W2334262022 cites W2033934239 @default.
• W2334262022 cites W2038682557 @default.
• W2334262022 cites W2040819013 @default.
• W2334262022 cites W2041014848 @default.
• W2334262022 cites W2041441742 @default.
• W2334262022 cites W2042706776 @default.
• W2334262022 cites W2043753702 @default.
• W2334262022 cites W2049191559 @default.
• W2334262022 cites W2049548547 @default.
• W2334262022 cites W2051202029 @default.
• W2334262022 cites W2056796552 @default.
• W2334262022 cites W2056854115 @default.
• W2334262022 cites W2059020082 @default.
• W2334262022 cites W2059287369 @default.
• W2334262022 cites W2059895391 @default.
• W2334262022 cites W2061423401 @default.
• W2334262022 cites W2062171946 @default.
• W2334262022 cites W2062466245 @default.
• W2334262022 cites W2067726729 @default.
• W2334262022 cites W2072382526 @default.
• W2334262022 cites W2075748541 @default.
• W2334262022 cites W2078584756 @default.
• W2334262022 cites W2081701708 @default.
• W2334262022 cites W2084479509 @default.
• W2334262022 cites W2085474141 @default.
• W2334262022 cites W2085481348 @default.
• W2334262022 cites W2087693039 @default.
• W2334262022 cites W2088093617 @default.
• W2334262022 cites W2089010458 @default.
• W2334262022 cites W2089119441 @default.
• W2334262022 cites W2090024422 @default.
• W2334262022 cites W2096816941 @default.
• W2334262022 cites W2128179591 @default.
• W2334262022 cites W2131350133 @default.
• W2334262022 cites W2146287923 @default.
• W2334262022 cites W2163746273 @default.
• W2334262022 cites W21802186 @default.
• W2334262022 cites W2323079892 @default.
• W2334262022 cites W2334230904 @default.
• W2334262022 cites W2494884191 @default.
• W2334262022 cites W29023494 @default.
• W2334262022 cites W2949827608 @default.
• W2334262022 cites W2950357152 @default.
• W2334262022 cites W2951851011 @default.
• W2334262022 cites W4235298239 @default.

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