Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334268129> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2334268129 endingPage "A80" @default.
- W2334268129 startingPage "A80.1" @default.
- W2334268129 abstract "<h3>Objectives</h3> Memory T cells are essential components of immunological memory, but little is known about their maintenance. Recirculating memory T cells of blood and secondary lymphoid organs slowly decay in numbers. In mice, we have recently identified professional resting memory CD4<sup>+</sup> T cells located in the BM and stably maintained in dedicated survival niches. The cells are resting, despite expression of CD69. Here we analyse and compare paired human peripheral blood (PB) and BM samples for phenotype, specificity and cytokine profiles of memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells. <h3>Material and Methods</h3> Mononuclear cells were isolated from paired PB and BM samples from individuals undergoing hip replacement surgery. Phenotypic analysis and cytokine profile of memory T-cells in response to CMV pp65, tetanus toxoid and measles were measured by flow cytometry. Proliferation and cell cycle status were analysed using Ki-67 and propidium iodide staining, respectively. Global transcription of cells was assessed by microarray analysis. <h3>Results</h3> Significantly higher numbers of memory T cells were found in BM than in PB. BM memory T cells displayed polyfunctionality, secreted a multitude of cytokines, and specificities for all recall antigens tested. They maintained long-lasting memory, even when it was not detectable in blood. CD69-expressing memory T cells were detected in BM but not in PB. Ki-67- and propidium iodide-positive cells were significantly lower in CD69<sup>+</sup> memory T cells from BM compared to PB. BM CD69<sup>+</sup> memory T cells showed a resting global gene expression profile. <h3>Conclusions</h3> BM is home to resting, professional memory CD4<sup>+</sup> and CD8<sup>+</sup>T cells, providing systemic, stable longterm memory." @default.
- W2334268129 created "2016-06-24" @default.
- W2334268129 creator A5003226722 @default.
- W2334268129 creator A5006949032 @default.
- W2334268129 creator A5017041605 @default.
- W2334268129 creator A5026796046 @default.
- W2334268129 creator A5032481510 @default.
- W2334268129 creator A5036755427 @default.
- W2334268129 creator A5037796324 @default.
- W2334268129 creator A5038174128 @default.
- W2334268129 creator A5040362165 @default.
- W2334268129 creator A5043272379 @default.
- W2334268129 creator A5044694911 @default.
- W2334268129 creator A5058279786 @default.
- W2334268129 creator A5078519912 @default.
- W2334268129 creator A5079589131 @default.
- W2334268129 creator A5082689005 @default.
- W2334268129 creator A5086735493 @default.
- W2334268129 creator A5088622402 @default.
- W2334268129 creator A5089758540 @default.
- W2334268129 date "2014-01-31" @default.
- W2334268129 modified "2023-10-02" @default.
- W2334268129 title "A8.10 Human memory t cells from the bone marrow are resting and maintain long-lasting memory" @default.
- W2334268129 doi "https://doi.org/10.1136/annrheumdis-2013-205124.184" @default.
- W2334268129 hasPublicationYear "2014" @default.
- W2334268129 type Work @default.
- W2334268129 sameAs 2334268129 @default.
- W2334268129 citedByCount "0" @default.
- W2334268129 crossrefType "journal-article" @default.
- W2334268129 hasAuthorship W2334268129A5003226722 @default.
- W2334268129 hasAuthorship W2334268129A5006949032 @default.
- W2334268129 hasAuthorship W2334268129A5017041605 @default.
- W2334268129 hasAuthorship W2334268129A5026796046 @default.
- W2334268129 hasAuthorship W2334268129A5032481510 @default.
- W2334268129 hasAuthorship W2334268129A5036755427 @default.
- W2334268129 hasAuthorship W2334268129A5037796324 @default.
- W2334268129 hasAuthorship W2334268129A5038174128 @default.
- W2334268129 hasAuthorship W2334268129A5040362165 @default.
- W2334268129 hasAuthorship W2334268129A5043272379 @default.
- W2334268129 hasAuthorship W2334268129A5044694911 @default.
- W2334268129 hasAuthorship W2334268129A5058279786 @default.
- W2334268129 hasAuthorship W2334268129A5078519912 @default.
- W2334268129 hasAuthorship W2334268129A5079589131 @default.
- W2334268129 hasAuthorship W2334268129A5082689005 @default.
- W2334268129 hasAuthorship W2334268129A5086735493 @default.
- W2334268129 hasAuthorship W2334268129A5088622402 @default.
- W2334268129 hasAuthorship W2334268129A5089758540 @default.
- W2334268129 hasConcept C147483822 @default.
- W2334268129 hasConcept C153911025 @default.
- W2334268129 hasConcept C167672396 @default.
- W2334268129 hasConcept C190283241 @default.
- W2334268129 hasConcept C203014093 @default.
- W2334268129 hasConcept C2775934118 @default.
- W2334268129 hasConcept C2776090121 @default.
- W2334268129 hasConcept C2777367678 @default.
- W2334268129 hasConcept C2780007613 @default.
- W2334268129 hasConcept C31573885 @default.
- W2334268129 hasConcept C553184892 @default.
- W2334268129 hasConcept C55493867 @default.
- W2334268129 hasConcept C71924100 @default.
- W2334268129 hasConcept C86803240 @default.
- W2334268129 hasConcept C8891405 @default.
- W2334268129 hasConceptScore W2334268129C147483822 @default.
- W2334268129 hasConceptScore W2334268129C153911025 @default.
- W2334268129 hasConceptScore W2334268129C167672396 @default.
- W2334268129 hasConceptScore W2334268129C190283241 @default.
- W2334268129 hasConceptScore W2334268129C203014093 @default.
- W2334268129 hasConceptScore W2334268129C2775934118 @default.
- W2334268129 hasConceptScore W2334268129C2776090121 @default.
- W2334268129 hasConceptScore W2334268129C2777367678 @default.
- W2334268129 hasConceptScore W2334268129C2780007613 @default.
- W2334268129 hasConceptScore W2334268129C31573885 @default.
- W2334268129 hasConceptScore W2334268129C553184892 @default.
- W2334268129 hasConceptScore W2334268129C55493867 @default.
- W2334268129 hasConceptScore W2334268129C71924100 @default.
- W2334268129 hasConceptScore W2334268129C86803240 @default.
- W2334268129 hasConceptScore W2334268129C8891405 @default.
- W2334268129 hasIssue "Suppl 1" @default.
- W2334268129 hasLocation W23342681291 @default.
- W2334268129 hasOpenAccess W2334268129 @default.
- W2334268129 hasPrimaryLocation W23342681291 @default.
- W2334268129 hasRelatedWork W1967215172 @default.
- W2334268129 hasRelatedWork W1969654549 @default.
- W2334268129 hasRelatedWork W2022120868 @default.
- W2334268129 hasRelatedWork W2069753690 @default.
- W2334268129 hasRelatedWork W2122932058 @default.
- W2334268129 hasRelatedWork W2348478326 @default.
- W2334268129 hasRelatedWork W2404073526 @default.
- W2334268129 hasRelatedWork W3147520661 @default.
- W2334268129 hasRelatedWork W4313407898 @default.
- W2334268129 hasRelatedWork W4319063722 @default.
- W2334268129 hasVolume "73" @default.
- W2334268129 isParatext "false" @default.
- W2334268129 isRetracted "false" @default.
- W2334268129 magId "2334268129" @default.
- W2334268129 workType "article" @default.