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- W2334283119 abstract "①von Willebrand因子(VWF)は,pH変化を感受することで,マルチマー形成,Weibel-Palade体への集積と分泌過程を制御することが明らかとなった.②VWFのA2ドメインの立体構造が解明され,ずり応力を感受してダイナミックにunfoldingし,ADAMTS13の切断部位を露出するよう設計されていることが明らかとなった.③VWFのA1ドメインとGPIbαとの相互作用は,2段階の結合様式を持つことが明らかとなった.④VWFのA1ドメイン隣接のO結合糖鎖はGPIbとの相互作用を調節し,A2ドメインのN結合糖鎖はADAMTS13感受性に関与することが示唆された." @default.
- W2334283119 created "2016-06-24" @default.
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- W2334283119 date "2013-01-01" @default.
- W2334283119 modified "2023-10-05" @default.
- W2334283119 title "Structure and function of von Willebrand factor, a shear- and pH-sensing plasma protein" @default.
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- W2334283119 doi "https://doi.org/10.2491/jjsth.24.68" @default.
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