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- W2334284920 abstract "Efforts toward the synthesis and process optimization of boceprevir 1 are described. Boceprevir synthesis was optimized by telescoping the first three steps and last two steps of the five-step process. Optimization of oxidation, which is one of the critical steps in the total synthesis, is discussed. A control strategy for the three impurities is described. A novel process for the synthesis of fragment A (2) has been developed, which is the key starting material for the synthesis of boceprevir." @default.
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- W2334284920 date "2014-08-08" @default.
- W2334284920 modified "2023-09-26" @default.
- W2334284920 title "Synthesis and Process Optimization of Boceprevir: A Protease Inhibitor Drug" @default.
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- W2334284920 doi "https://doi.org/10.1021/op500065t" @default.
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