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- W2334285437 abstract "P chemotherapy, such as cisplatin, is the primary treatment for ovarian cancer. However, drug resistance has become a major impediment to the successful treatment of ovarian cancer. To date, the molecular mechanisms of resistance to platinum-based chemotherapy remain unclear. In our previous study using a proteomic approach, more than 90 proteins showed significant expression changes when two pairs of ovarian cancer cell lines, A2780/A2780-CP (cisplatinsensitive/cisplatin-resistant) and 2008/2008-C13*5.25 (cisplatin-sensitive/cisplatin-resistant), were compared. Bioinformatics analysis suggested several potential pathways that may be involved in platinum resistance. Among these potential pathways, a redox regulated pathway involving superoxide dismutase 1 (SOD1) was targeted in order to further explore its involvement in drug resistance. Inhibition of SOD1 activity in the resistant cells by either small-molecule inhibitors or siRNA enabled partial reversal of platinum resistance. Our data suggest that targeting SOD1 can potentially lead to sensitization of platinum-resistant ovarian cancer cells, and SOD1 may be used as a therapeutic target for chemosensitization of ovarian cancer." @default.
- W2334285437 created "2016-06-24" @default.
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- W2334285437 date "2011-01-01" @default.
- W2334285437 modified "2023-09-28" @default.
- W2334285437 title "Targeting superoxide dismutase 1 for chemosensitization of platinum resistant ovarian cancer cells" @default.
- W2334285437 hasPublicationYear "2011" @default.
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