Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334286064> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2334286064 endingPage "376" @default.
- W2334286064 startingPage "371" @default.
- W2334286064 abstract "In this study, we evaluated the effect of chemotherapy (CT) and thoracic radiotherapy (RT) integration and the timing of RT on survival of elderly patients with limited-stage small-cell lung cancer. Eighty patients were retrospectively analyzed. All the patients revived thoracic RT and 70 patients received ≥2 cycles of CT. Twenty-two patients received RT sequentially to CT, 19 with RT consolidated with CT, and 29 with RT concurrent with CT. Early chest irradiation was defined as beginning RT after 1–3 cycles of CT (n = 44), and late chest irradiation was defined as occurring after ≥4 cycles of CT (n = 26). Twenty-six patients (32.5%) achieved complete response, 37 (46.2%) partial response, 10 (12.5%) stable disease, and 7 (8.7%) progressive disease. The median survival time for all patients was 19 months. The 1-, 2-, and 3-year overall survival (OS) rates were 68.9%, 41.3%, and 31.7%, respectively. In univariate analyses, the volume of the primary tumor, CT, treatment modality, timing of RT, target volume, and RT dose were significantly associated with OS. At 3 years, concomitant chemoradiotherapy was superior to consolidated and sequential chemoradiotherapy (40.0% vs. 36.9% vs. 40.0%, respectively). The rate of OS at 3 years was 37.1% for patients receiving early-RT and 27.8% for those receiving late-RT (P = 0.006). Multivariate analysis showed that CT and RT dose were independent factors influencing OS. Concurrent chemoradiotherapy resulted in a high survival rate. A radiation dose–response relationship was observed, and a dose of at least 60-Gy daily radiation demonstrated improved survival." @default.
- W2334286064 created "2016-06-24" @default.
- W2334286064 creator A5036650726 @default.
- W2334286064 creator A5039924898 @default.
- W2334286064 creator A5064711465 @default.
- W2334286064 creator A5074640554 @default.
- W2334286064 creator A5082692509 @default.
- W2334286064 creator A5090012174 @default.
- W2334286064 date "2014-09-01" @default.
- W2334286064 modified "2023-09-29" @default.
- W2334286064 title "A Study of Elderly Patients With Limited-Stage Small-Cell Lung Cancer After Combined Chemoradiotherapy" @default.
- W2334286064 cites W1481967818 @default.
- W2334286064 cites W1839070320 @default.
- W2334286064 cites W1884032213 @default.
- W2334286064 cites W1885320430 @default.
- W2334286064 cites W1905406155 @default.
- W2334286064 cites W1920090590 @default.
- W2334286064 cites W1984733885 @default.
- W2334286064 cites W1995804719 @default.
- W2334286064 cites W1996661703 @default.
- W2334286064 cites W2076643424 @default.
- W2334286064 cites W2124353451 @default.
- W2334286064 cites W2150878803 @default.
- W2334286064 cites W2160012348 @default.
- W2334286064 cites W2323020638 @default.
- W2334286064 doi "https://doi.org/10.1097/mjt.0b013e3182541cb3" @default.
- W2334286064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22975663" @default.
- W2334286064 hasPublicationYear "2014" @default.
- W2334286064 type Work @default.
- W2334286064 sameAs 2334286064 @default.
- W2334286064 citedByCount "2" @default.
- W2334286064 countsByYear W23342860642023 @default.
- W2334286064 crossrefType "journal-article" @default.
- W2334286064 hasAuthorship W2334286064A5036650726 @default.
- W2334286064 hasAuthorship W2334286064A5039924898 @default.
- W2334286064 hasAuthorship W2334286064A5064711465 @default.
- W2334286064 hasAuthorship W2334286064A5074640554 @default.
- W2334286064 hasAuthorship W2334286064A5082692509 @default.
- W2334286064 hasAuthorship W2334286064A5090012174 @default.
- W2334286064 hasConcept C126322002 @default.
- W2334286064 hasConcept C126838900 @default.
- W2334286064 hasConcept C143998085 @default.
- W2334286064 hasConcept C144301174 @default.
- W2334286064 hasConcept C146357865 @default.
- W2334286064 hasConcept C151730666 @default.
- W2334286064 hasConcept C2776256026 @default.
- W2334286064 hasConcept C2776694085 @default.
- W2334286064 hasConcept C2778424827 @default.
- W2334286064 hasConcept C2778822529 @default.
- W2334286064 hasConcept C2779384505 @default.
- W2334286064 hasConcept C2989005 @default.
- W2334286064 hasConcept C38180746 @default.
- W2334286064 hasConcept C509974204 @default.
- W2334286064 hasConcept C71924100 @default.
- W2334286064 hasConcept C86803240 @default.
- W2334286064 hasConceptScore W2334286064C126322002 @default.
- W2334286064 hasConceptScore W2334286064C126838900 @default.
- W2334286064 hasConceptScore W2334286064C143998085 @default.
- W2334286064 hasConceptScore W2334286064C144301174 @default.
- W2334286064 hasConceptScore W2334286064C146357865 @default.
- W2334286064 hasConceptScore W2334286064C151730666 @default.
- W2334286064 hasConceptScore W2334286064C2776256026 @default.
- W2334286064 hasConceptScore W2334286064C2776694085 @default.
- W2334286064 hasConceptScore W2334286064C2778424827 @default.
- W2334286064 hasConceptScore W2334286064C2778822529 @default.
- W2334286064 hasConceptScore W2334286064C2779384505 @default.
- W2334286064 hasConceptScore W2334286064C2989005 @default.
- W2334286064 hasConceptScore W2334286064C38180746 @default.
- W2334286064 hasConceptScore W2334286064C509974204 @default.
- W2334286064 hasConceptScore W2334286064C71924100 @default.
- W2334286064 hasConceptScore W2334286064C86803240 @default.
- W2334286064 hasIssue "5" @default.
- W2334286064 hasLocation W23342860641 @default.
- W2334286064 hasLocation W23342860642 @default.
- W2334286064 hasOpenAccess W2334286064 @default.
- W2334286064 hasPrimaryLocation W23342860641 @default.
- W2334286064 hasRelatedWork W1975479077 @default.
- W2334286064 hasRelatedWork W1988030834 @default.
- W2334286064 hasRelatedWork W2094820734 @default.
- W2334286064 hasRelatedWork W2234839489 @default.
- W2334286064 hasRelatedWork W2277416945 @default.
- W2334286064 hasRelatedWork W2363865786 @default.
- W2334286064 hasRelatedWork W2375386244 @default.
- W2334286064 hasRelatedWork W2407189953 @default.
- W2334286064 hasRelatedWork W2430773826 @default.
- W2334286064 hasRelatedWork W1899415052 @default.
- W2334286064 hasVolume "21" @default.
- W2334286064 isParatext "false" @default.
- W2334286064 isRetracted "false" @default.
- W2334286064 magId "2334286064" @default.
- W2334286064 workType "article" @default.