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- W2334291237 abstract "Rationale: We have previously shown that PBEF, a cytozyme with extracellular proinflammatory cytokine-like activity and intracellular enzymatic activity as a phosphoribosyltransferase, which regulates intracellular NAD levels, cellular redox state, histone deacetylases and inhibits apoptosis, is significantly upregulated in patients with pulmonary arterial hypertension. We sought to determine whether inhibition of the cytokine and enzymatic activities of PBEF could prevent and reverse monocrotaline (MCT)-induced pulmonary hypertension (PH) in rats. In addition, we hypothesized that PBEF could affect calcium signaling pathways, which play a role in cell proliferation and vascular constriction. Methods: Male Sprague-Dawley rats (n=6 per group) received one dose of MCT (60 mg/kg, IP). In the prevention experiments, rats were simultaneously administrated FK866 (an inhibitor of PBEF enzymatic activity) (2.5 mg/kg, IP, twice daily for 2wks) or recombinant goat μ anti-PBEF antibody (20 g/kg, IP, daily for 2wks). In the reversal experiments, the same doses, frequency and duration of FK866 or PBEF antibodies were given 2wks after MCT. Right ventricular systolic pressure (RVSP) was determined with a pressure transducer catheter. The right ventricle: left ventricle +septum (RV/LV+S) ratio was calculated. In a cell culture model, human pulmonary arterial smooth muscle cells" @default.
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- W2334291237 date "2012-05-01" @default.
- W2334291237 modified "2023-09-22" @default.
- W2334291237 title "Inhibition Of Pre-B Cell Colony-Enhancing Factor (PBEF) Prevents And Reverses Monocrotaline-Induced Pulmonary Hypertension" @default.
- W2334291237 doi "https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3914" @default.
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