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• W2334293737 abstract "A new strategy for cancer gene therapy has been developed using a plant gene which encodes the enzyme, linamarase, that hydrolyzes the cyanogenic glucoside substrate, linamarin, into glucose, acetone and cyanide. Retroviral vectors that carry linamarase as a potential killer–suicide gene cause a marked sensitization to the innocuous substrate, linamarin, followed by cell death. We show that the system can eradicate very large intracerebral gliomas in vivo helped by a cyanide bystander effect. Animals showing a total regression of the tumor by magnetic resonance imaging (MRI), do not show other appreciable toxic effects." @default.
• W2334293737 created "2016-06-24" @default.
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• W2334293737 date "1998-11-01" @default.
• W2334293737 modified "2023-10-10" @default.
• W2334293737 title "Successful use of a plant gene in the treatment of cancer in vivo" @default.
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• W2334293737 doi "https://doi.org/10.1038/sj.gt.3300751" @default.
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