FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334302142> ?p ?o ?g. }

• W2334302142 endingPage "150" @default.
• W2334302142 startingPage "150" @default.
• W2334302142 abstract "Background: Living donation is increasingly being carried out in the context of the secular trend of increasing prevalence of the metabolic syndrome (MS) worldwide. There is a paucity of data on the associations between metabolic syndrome at donation and 1) the presence of histologic abnormalities including acute tubular necrosis (ATN) among living kidney donors (LD) and 2) post donation kidney function Hypothesis: The presence of features of MS in the living donor would be associated with greater prevalence of histologic abnomalities and decreased renal function. Setting/Study Population/Methods: The sample for this restrospective analysis consisted of 459 living donors with implant biopsy (IMBx), of which 268 had at least 3 months of follow up and 142 had at least up to 2 years of follow up. MS was present in 65/459 (14.2%) donors. We studied associations between MS, kidney volume, kidney histology and renal function in a multivariate modelTable: [Donor characteristics by presence/absence of MS]Results: Donors with MS were more likely to be men and older; MS prevalence did not differ by race. By definition, donors with MS were more likely to be hypertensive and heavier. Masked hypertension (24-hour ABPM) was not different between groups. Donors with MS were also more likely to have elevated levels of total cholesterol (213±54 vs. 189±37 mg/dl, p< 0.01), LDL (130±47 vs. 110±34 mg/dl, p< 0.01) and uric acid (5.7±1.2 vs. 4.9±1.2, p< 0.01). Kidney volumes adjusted for body surface area were not different between groups (p=0.277), but donors with MS were more likely than donors without MS to have an abnormal histology (p=0.001). Various degrees of ATN likely stemming from the nephrectomy process were more likely in donors with MS than in healthier donors (p=0.049). While abnormal histology did not relate to kidney volumes, those with abnormal histology were more likely to have a lower GFR (104±15 vs. 108±16 ml/min/1.72 m2, p=0.035). There was also a statistically significant correlation between kidney volumes and GFR (p< 0.01). Conclusions: Histologic abnormalities in the donated kidney are more common among donors with MS and are associated with lower donor GFR. The long term implications of MS on donor health and renal function merit further study" @default.
• W2334302142 created "2016-06-24" @default.
• W2334302142 creator A5021944743 @default.
• W2334302142 creator A5023492452 @default.
• W2334302142 creator A5043195515 @default.
• W2334302142 creator A5049551716 @default.
• W2334302142 creator A5070667307 @default.
• W2334302142 date "2012-11-01" @default.
• W2334302142 modified "2023-09-23" @default.
• W2334302142 title "Associations Between Metabolic Syndrome and Kidney Histology, Anatomy and Function among Living Kidney Donors" @default.
• W2334302142 doi "https://doi.org/10.1097/00007890-201211271-00278" @default.
• W2334302142 hasPublicationYear "2012" @default.
• W2334302142 type Work @default.
• W2334302142 sameAs 2334302142 @default.
• W2334302142 citedByCount "0" @default.
• W2334302142 crossrefType "journal-article" @default.
• W2334302142 hasAuthorship W2334302142A5021944743 @default.
• W2334302142 hasAuthorship W2334302142A5023492452 @default.
• W2334302142 hasAuthorship W2334302142A5043195515 @default.
• W2334302142 hasAuthorship W2334302142A5049551716 @default.
• W2334302142 hasAuthorship W2334302142A5070667307 @default.
• W2334302142 hasBestOaLocation W23343021421 @default.
• W2334302142 hasConcept C126322002 @default.
• W2334302142 hasConcept C151730666 @default.
• W2334302142 hasConcept C159641895 @default.
• W2334302142 hasConcept C2775934546 @default.
• W2334302142 hasConcept C2779343474 @default.
• W2334302142 hasConcept C2779881121 @default.
• W2334302142 hasConcept C2780091579 @default.
• W2334302142 hasConcept C2780578515 @default.
• W2334302142 hasConcept C2908647359 @default.
• W2334302142 hasConcept C42407357 @default.
• W2334302142 hasConcept C511355011 @default.
• W2334302142 hasConcept C57742111 @default.
• W2334302142 hasConcept C71924100 @default.
• W2334302142 hasConcept C86803240 @default.
• W2334302142 hasConcept C99454951 @default.
• W2334302142 hasConceptScore W2334302142C126322002 @default.
• W2334302142 hasConceptScore W2334302142C151730666 @default.
• W2334302142 hasConceptScore W2334302142C159641895 @default.
• W2334302142 hasConceptScore W2334302142C2775934546 @default.
• W2334302142 hasConceptScore W2334302142C2779343474 @default.
• W2334302142 hasConceptScore W2334302142C2779881121 @default.
• W2334302142 hasConceptScore W2334302142C2780091579 @default.
• W2334302142 hasConceptScore W2334302142C2780578515 @default.
• W2334302142 hasConceptScore W2334302142C2908647359 @default.
• W2334302142 hasConceptScore W2334302142C42407357 @default.
• W2334302142 hasConceptScore W2334302142C511355011 @default.
• W2334302142 hasConceptScore W2334302142C57742111 @default.
• W2334302142 hasConceptScore W2334302142C71924100 @default.
• W2334302142 hasConceptScore W2334302142C86803240 @default.
• W2334302142 hasConceptScore W2334302142C99454951 @default.
• W2334302142 hasIssue "10S" @default.
• W2334302142 hasLocation W23343021421 @default.
• W2334302142 hasOpenAccess W2334302142 @default.
• W2334302142 hasPrimaryLocation W23343021421 @default.
• W2334302142 hasRelatedWork W1964173876 @default.
• W2334302142 hasRelatedWork W1973757701 @default.
• W2334302142 hasRelatedWork W2042572388 @default.
• W2334302142 hasRelatedWork W2080298256 @default.
• W2334302142 hasRelatedWork W2135938945 @default.
• W2334302142 hasRelatedWork W2332797408 @default.
• W2334302142 hasRelatedWork W2380389674 @default.
• W2334302142 hasRelatedWork W3026994088 @default.
• W2334302142 hasRelatedWork W2341230246 @default.
• W2334302142 hasRelatedWork W3121641278 @default.
• W2334302142 hasVolume "94" @default.
• W2334302142 isParatext "false" @default.
• W2334302142 isRetracted "false" @default.
• W2334302142 magId "2334302142" @default.
• W2334302142 workType "article" @default.