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- W2334302509 abstract "<h3>Background</h3> Periprosthetic joint infection is a rare but potentially serious complication. In 2012, Parvizi et al. suggested intra-articular C-reactive protein (CRP) could be used as a diagnosis marker of periprosthetic joint infection, with a threshold of 9.5mg/L<sup>1</sup>. <h3>Objectives</h3> The aim of our study was to analyse variations of CRP in synovial fluid between patients with native or prosthetic knee and find a threshold predictive of prosthetic knee infection. <h3>Methods</h3> From February to August 2012, 31 patients were included in our study: 10 patients with effusion in their native joint, 11 with aseptic effusion on prosthetic knee, 10 patients with a prosthetic knee infection according to the 2011 Muskuloskeletal Society criteria. All cases underwent joint aspiration. Intra-articular CRP level was determined by nephelometry and compared to seric CRP. <h3>Results</h3> Intra-articular CRP level was increased in patients with prosthetic knee infection compared to patients without prosthesis or aseptic prosthesis (respectively 24.4mg/L, 1.91 mg/L, 3.69mg/L; p=0.012, p<0.001). We used ROC curves using intra-articular CRP level from both prosthetic groups. A threshold of 2.78 mg/L might define a possible infection (sensibility 100%, specificity 81.82%), a threshold of 5.37 mg/L might define a probable infection (sensibility 90%, specificity 90.91%). Area under curve were not different for intra-articular CRP level (0.90) and seric CRP level (0.98). <h3>Conclusions</h3> Our study showed that intra-articular CRP level could be a useful marker of prosthetic knee infection. The exact usefulness of this marker for the diagnosis of periprosthetic joint infection needs to be more precisely evaluated on a larger cohort. <h3>References</h3> Parvizi J, McKenzie JC, Cashman JP. <i>J Arthroplasty</i>. 2012 Sep;27(8 Suppl):12-6 <h3>Disclosure of Interest</h3> None Declared" @default.
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- W2334302509 date "2013-06-01" @default.
- W2334302509 modified "2023-10-17" @default.
- W2334302509 title "AB0646 Intra-articular level of c-reactive protein in diagnosis of prosthetic knee infection" @default.
- W2334302509 doi "https://doi.org/10.1136/annrheumdis-2013-eular.2968" @default.
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