FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334342212> ?p ?o ?g. }

• W2334342212 endingPage "712" @default.
• W2334342212 startingPage "704" @default.
• W2334342212 abstract "Previously we showed that blocking the endothelin (ET)A receptor subtype with BQ-153 inhibited the vasoconstrictor effects of intravenously administered ET-1. In the presence of the ETA antagonist, ET-1 produced marked reductions in myocardial contractility and renal blood flow. We postulated that either the ETB receptor, or some other, as yet unidentified, ET-receptor subtype mediated the observed hemodynamic changes. In anesthetized pigs, this hypothesis was tested by using a recently developed selective, high-affinity antagonist to the ETB receptor, BQ-788, and sarafotoxin S6c, a selective ETB agonist, to determine the contribution of this receptor subtype to cardiovascular function. Endothelin-1 (0.4 nmol/kg, i.v.) produced the characteristic biphasic hemodynamic responses, consisting of an initial transient reduction in mean arterial pressure (MAP; 83 ± 3 to 72 ± 4 mm Hg; n = 9) followed by a prolonged increase (112 ± 4 mm Hg; p < 0.01). As well, cardiac output (−58%; p < 0.05), myocardial contractility (−19%; p < 0.01), and renal blood flow (−63%; p < 0.05) decreased. Sarafotoxin S6c produced marked but transient reductions in MAP (p < 0.001), cardiac output (p < 0.01), myocardial contractility (p < 0.001), and renal blood flow (p < 0.05). BQ-788 (1.0 mg/kg, i.v.), administered 3 min before sarafotoxin S6c, inhibited its effects. BQ-788 also inhibited the initial transient reduction in MAP seen after the injection of ET-1, but the subsequent sustained pressor responses were enhanced as reflected in the greater increases in left ventricular pressure (p < 0.02), myocardial contractility (p < 0.05), MAP (p < 0.01), and a larger reduction in cardiac output (p < 0.05). The heart rate was not changed after the initial ET injection, but it increased 54% when the peptide was administered in the presence of BQ-788. The reduction in renal blood flow was still evident, and its magnitude (64%) remained the same (p < 0.01) after treatment with BQ-788. Only the combined administration of both the ETA (BQ-123) and ETB (BQ-788) receptor antagonists blocked the effects of ET-1 on renal blood flow (p < 0.05). These data confirm that BQ-788 is a selective and effective antagonist of the ETB receptor and show that activation of this receptor subtype is involved in the transient vasodilation provoked by ET-1. Additionally, the ETB receptor appears to oppose the vasoconstrictor effects of the ETA receptor, which clearly mediates vasoconstriction. Combined treatment with BQ-123 and BQ-788 attenuated the reductions in renal blood flow produced by ET-1. Furthermore, some actions of ET-1 were not blocked by these antagonists and cannot be attributed to either the ETA or ETB receptors. We hypothesize the existence of an additional ET receptor or a subtype of the ETB receptor that is insensitive to BQ-788." @default.
• W2334342212 created "2016-06-24" @default.
• W2334342212 creator A5018363689 @default.
• W2334342212 creator A5022157246 @default.
• W2334342212 creator A5043704885 @default.
• W2334342212 creator A5087742067 @default.
• W2334342212 date "1997-06-01" @default.
• W2334342212 modified "2023-09-27" @default.
• W2334342212 title "Cardiovascular and Renal Actions of the EndothelinB Receptor in Pigs" @default.
• W2334342212 cites W1544252040 @default.
• W2334342212 cites W18385981 @default.
• W2334342212 cites W1970616759 @default.
• W2334342212 cites W1978927149 @default.
• W2334342212 cites W1981910970 @default.
• W2334342212 cites W1994225897 @default.
• W2334342212 cites W2035076101 @default.
• W2334342212 cites W2043143761 @default.
• W2334342212 cites W2046102701 @default.
• W2334342212 cites W2050300694 @default.
• W2334342212 cites W2054381541 @default.
• W2334342212 cites W2054733362 @default.
• W2334342212 cites W2059369537 @default.
• W2334342212 cites W2067948588 @default.
• W2334342212 cites W2070233169 @default.
• W2334342212 cites W2084066477 @default.
• W2334342212 cites W2124101537 @default.
• W2334342212 cites W2151869895 @default.
• W2334342212 cites W2067693553 @default.
• W2334342212 doi "https://doi.org/10.1097/00005344-199706000-00002" @default.
• W2334342212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9234650" @default.
• W2334342212 hasPublicationYear "1997" @default.
• W2334342212 type Work @default.
• W2334342212 sameAs 2334342212 @default.
• W2334342212 citedByCount "24" @default.
• W2334342212 countsByYear W23343422122016 @default.
• W2334342212 crossrefType "journal-article" @default.
• W2334342212 hasAuthorship W2334342212A5018363689 @default.
• W2334342212 hasAuthorship W2334342212A5022157246 @default.
• W2334342212 hasAuthorship W2334342212A5043704885 @default.
• W2334342212 hasAuthorship W2334342212A5087742067 @default.
• W2334342212 hasBestOaLocation W23343422121 @default.
• W2334342212 hasConcept C126322002 @default.
• W2334342212 hasConcept C134018914 @default.
• W2334342212 hasConcept C139940330 @default.
• W2334342212 hasConcept C142225936 @default.
• W2334342212 hasConcept C144980905 @default.
• W2334342212 hasConcept C158846371 @default.
• W2334342212 hasConcept C170493617 @default.
• W2334342212 hasConcept C178853913 @default.
• W2334342212 hasConcept C185592680 @default.
• W2334342212 hasConcept C2776452961 @default.
• W2334342212 hasConcept C2776885963 @default.
• W2334342212 hasConcept C2777953023 @default.
• W2334342212 hasConcept C2778122271 @default.
• W2334342212 hasConcept C2778938600 @default.
• W2334342212 hasConcept C2781073237 @default.
• W2334342212 hasConcept C39133596 @default.
• W2334342212 hasConcept C71924100 @default.
• W2334342212 hasConcept C84393581 @default.
• W2334342212 hasConceptScore W2334342212C126322002 @default.
• W2334342212 hasConceptScore W2334342212C134018914 @default.
• W2334342212 hasConceptScore W2334342212C139940330 @default.
• W2334342212 hasConceptScore W2334342212C142225936 @default.
• W2334342212 hasConceptScore W2334342212C144980905 @default.
• W2334342212 hasConceptScore W2334342212C158846371 @default.
• W2334342212 hasConceptScore W2334342212C170493617 @default.
• W2334342212 hasConceptScore W2334342212C178853913 @default.
• W2334342212 hasConceptScore W2334342212C185592680 @default.
• W2334342212 hasConceptScore W2334342212C2776452961 @default.
• W2334342212 hasConceptScore W2334342212C2776885963 @default.
• W2334342212 hasConceptScore W2334342212C2777953023 @default.
• W2334342212 hasConceptScore W2334342212C2778122271 @default.
• W2334342212 hasConceptScore W2334342212C2778938600 @default.
• W2334342212 hasConceptScore W2334342212C2781073237 @default.
• W2334342212 hasConceptScore W2334342212C39133596 @default.
• W2334342212 hasConceptScore W2334342212C71924100 @default.
• W2334342212 hasConceptScore W2334342212C84393581 @default.
• W2334342212 hasIssue "6" @default.
• W2334342212 hasLocation W23343422121 @default.
• W2334342212 hasLocation W23343422122 @default.
• W2334342212 hasOpenAccess W2334342212 @default.
• W2334342212 hasPrimaryLocation W23343422121 @default.
• W2334342212 hasRelatedWork W1967076066 @default.
• W2334342212 hasRelatedWork W1979290169 @default.
• W2334342212 hasRelatedWork W1980111066 @default.
• W2334342212 hasRelatedWork W1992466120 @default.
• W2334342212 hasRelatedWork W2035202002 @default.
• W2334342212 hasRelatedWork W2090116442 @default.
• W2334342212 hasRelatedWork W2130893278 @default.
• W2334342212 hasRelatedWork W2334342212 @default.
• W2334342212 hasRelatedWork W2393521223 @default.
• W2334342212 hasRelatedWork W2582971951 @default.
• W2334342212 hasVolume "29" @default.
• W2334342212 isParatext "false" @default.
• W2334342212 isRetracted "false" @default.
• W2334342212 magId "2334342212" @default.
• W2334342212 workType "article" @default.