Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334352662> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2334352662 endingPage "P2470" @default.
- W2334352662 startingPage "P2470" @default.
- W2334352662 abstract "Purpose: Endothelin-1 (ET-1) is a potent endothelial cell-derived peptide with multifunctional properties including venous and arterial vasoconstrictor properties, the ability to modulate inotropy and to induce myocardium hypertrophy. We evaluated circulating levels of ET-1 in patients with systolic chronic heart failure (HF) and comorbid diabetes mellitus type 2 (DM2) in relation to the levels of B-type natriuretic peptide (NT-proBNP) and echocardiographic parameters of diastolic function. Methods: ET-1 plasma level was assessed by an enzyme-linked immunoassay in patients with systolic HF (n=30), systolic HF+DM2 patients (n=25) and healthy volunteers (n=20). NT-proBNP was measured in serum samples with a fully automated sandwich immunoassay. Results: There was no difference in NYHA functional class and left ventricular ejection fraction (LV EF) between HF groups, but patients with HF+DM2 had more severe LV diastolic dysfunction. The ET-1 plasma levels of HF+DM2 patients was higher than in patients with HF without DM2 (794 [567; 1142] vs 487 [423; 629], p=0.0005) and healthy subjects (432 [358; 543], p=0.0001). The correlations between ET-1 plasma levels and NT-proBNP (r=0.38, p=0.0002), LV end-diastolic volume (r=0.32, p=0.008), mitral E/A ratio (r=0.47, p<0.0001), isovolumetric relaxation time (r= -0.30; p=0.015), LV EF (r= -0.27, p=0.025) were found in a combined group of patients. ET-1 plasma levels was higher in HF patients with moderate/severe LV diastolic dysfunction (stages II-III) compared to patients with mild LV diastolic dysfunction (stage I) (814 [618; 1203] vs 543 [462; 704] p<0.0001). Conclusions: These findings indicate that plasma endothelin-1 level in patients with systolic HF can be considered as a potential biomarker of LV diastolic dysfunction worsening by diabetic related co-morbidity." @default.
- W2334352662 created "2016-06-24" @default.
- W2334352662 creator A5000426248 @default.
- W2334352662 creator A5017872517 @default.
- W2334352662 creator A5019292967 @default.
- W2334352662 creator A5021511753 @default.
- W2334352662 creator A5034238389 @default.
- W2334352662 creator A5076807922 @default.
- W2334352662 creator A5083757966 @default.
- W2334352662 date "2013-08-02" @default.
- W2334352662 modified "2023-09-27" @default.
- W2334352662 title "Circulating level of endothelin-1 in patients with chronic systolic heart failure correlates with the degree of diastolic dysfunction and type 2 diabetes co-morbidity" @default.
- W2334352662 doi "https://doi.org/10.1093/eurheartj/eht308.p2470" @default.
- W2334352662 hasPublicationYear "2013" @default.
- W2334352662 type Work @default.
- W2334352662 sameAs 2334352662 @default.
- W2334352662 citedByCount "0" @default.
- W2334352662 crossrefType "journal-article" @default.
- W2334352662 hasAuthorship W2334352662A5000426248 @default.
- W2334352662 hasAuthorship W2334352662A5017872517 @default.
- W2334352662 hasAuthorship W2334352662A5019292967 @default.
- W2334352662 hasAuthorship W2334352662A5021511753 @default.
- W2334352662 hasAuthorship W2334352662A5034238389 @default.
- W2334352662 hasAuthorship W2334352662A5076807922 @default.
- W2334352662 hasAuthorship W2334352662A5083757966 @default.
- W2334352662 hasBestOaLocation W23343526621 @default.
- W2334352662 hasConcept C126322002 @default.
- W2334352662 hasConcept C134018914 @default.
- W2334352662 hasConcept C155710745 @default.
- W2334352662 hasConcept C164705383 @default.
- W2334352662 hasConcept C2775915353 @default.
- W2334352662 hasConcept C2778198053 @default.
- W2334352662 hasConcept C39078644 @default.
- W2334352662 hasConcept C555293320 @default.
- W2334352662 hasConcept C57900726 @default.
- W2334352662 hasConcept C71924100 @default.
- W2334352662 hasConcept C78085059 @default.
- W2334352662 hasConcept C84393581 @default.
- W2334352662 hasConceptScore W2334352662C126322002 @default.
- W2334352662 hasConceptScore W2334352662C134018914 @default.
- W2334352662 hasConceptScore W2334352662C155710745 @default.
- W2334352662 hasConceptScore W2334352662C164705383 @default.
- W2334352662 hasConceptScore W2334352662C2775915353 @default.
- W2334352662 hasConceptScore W2334352662C2778198053 @default.
- W2334352662 hasConceptScore W2334352662C39078644 @default.
- W2334352662 hasConceptScore W2334352662C555293320 @default.
- W2334352662 hasConceptScore W2334352662C57900726 @default.
- W2334352662 hasConceptScore W2334352662C71924100 @default.
- W2334352662 hasConceptScore W2334352662C78085059 @default.
- W2334352662 hasConceptScore W2334352662C84393581 @default.
- W2334352662 hasIssue "suppl 1" @default.
- W2334352662 hasLocation W23343526621 @default.
- W2334352662 hasOpenAccess W2334352662 @default.
- W2334352662 hasPrimaryLocation W23343526621 @default.
- W2334352662 hasRelatedWork W2051712573 @default.
- W2334352662 hasRelatedWork W2153658479 @default.
- W2334352662 hasRelatedWork W2189600054 @default.
- W2334352662 hasRelatedWork W2328354663 @default.
- W2334352662 hasRelatedWork W2376801220 @default.
- W2334352662 hasRelatedWork W2383671142 @default.
- W2334352662 hasRelatedWork W2779222010 @default.
- W2334352662 hasRelatedWork W2965474825 @default.
- W2334352662 hasRelatedWork W3155674270 @default.
- W2334352662 hasRelatedWork W3187572025 @default.
- W2334352662 hasVolume "34" @default.
- W2334352662 isParatext "false" @default.
- W2334352662 isRetracted "false" @default.
- W2334352662 magId "2334352662" @default.
- W2334352662 workType "article" @default.