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- W2334355301 abstract "Objectives : The experiment was performed to investigate promotive effects of haeae-tang (HET) extract, a traditional Korean medicinal recipe, on hair growth, protein and gene expression in hair-removed C57BL/6. Methods : In experiment, animals were divided into 3 groups including normal (vehicle), HET ethanol extract and 5% minoxidil-treated groups (Minoxidil, positive control). The vehicle or testing samples were daily treated with 0.2ml per on hair-shaved dorsal skin of C57BL/6mice for 15 days. Effects of testing samples on hair growth was monitored through phototrichogram analysis by folliscope on the initial, <TEX>$5^{th}$</TEX>, <TEX>$10^{th}$</TEX>, <TEX>$15^{th}$</TEX> day, respectively. Also, gene and protein expressions of vascular endothelial growth factor (VEGF) and Insulin like growth factor-1 (IGF-1), relevant to hair growth, were examined. Results : Hair density and hair thickness of Minoxidil treated-group was significantly increased compared to that of vehicle application on the <TEX>$15^{th}$</TEX>day, respectively. Dorsal hair density of HET treated-group was significantly increased compared to that of vehicle application on the <TEX>$15^{th}$</TEX>day. In addition, the Minoxidil group significantly increased the expression of cutaneous IGF-1 protein and mRNA compared to that of the vehicle-applied group on the <TEX>$15^{th}$</TEX> day. And HET-treated group significantly increased the expression of dorsal VEGF protein compared to that of the vehicle-applied group on the <TEX>$15^{th}$</TEX> day. Conclusions : These results suggest that this Korean medicinal recipe, HET has promoting activity on hair growth in an Alopecia animal model thus it can be used as a material of agent or products for improvement or prevention of alopecia." @default.
- W2334355301 created "2016-06-24" @default.
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- W2334355301 date "2015-03-30" @default.
- W2334355301 modified "2023-10-16" @default.
- W2334355301 title "Haeae-tang including Artemisia argyi Folium promotes hair growth in hair-removed C57BL/6 Mice" @default.
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- W2334355301 doi "https://doi.org/10.6116/kjh.2015.30.2.19" @default.
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