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- W2334387589 abstract "The physiological significance of endogenous prostaglandin (PG) on spontaneous contractions in isolated circular muscles of the guinea-pig stomach was investigated.Contents of the E and F types of PG were measured by radioimmunoassay as PGE2 and PGF2α.The isolated circular muscles contained 17.04±2.12ng PGE2/g tissue (n=12) and 9.38±0.62ng PGF2α/g tissue (n=12), and released 0.36±0.04ng PGE2/g tissue/min (n=10) and 0.14±0.01 ng PGF2α/g tissue/min (n=12) into the solution. These contents and releases of PGs were reduced by treatment with indomethacin (ID50=0.3μEg/ml).Indomethacin (0.1-6μEg/ml) increased the amplitude of spontaneous contractions dosedependently, while high concentrations (20μEg/ml) conversely depressed it.Physiological concentrations of exogenously applied PGE2 (0.03-0.35ng/ml) markedly suppressed spontaneous contractions in the presence and absence of indomethacin (3μEg/ml), while PGF2α in concentrations of 0.35-3.54ng/ml slightly increased them. Therefore, these results suggested that spontaneous contractions in circular muscles were largely influenced by the E type of endogenous PG, not by the F type. The indomethacin-induced increase in the amplitude of spontaneous contractions was not affected by intrinsic nerves and was accompanied by an increase in spike discharges on the slow wave and 45Ca uptake in the muscle cells.These observations suggested that the E type of endogenous PG in circular muscles might play a suppressive role in spontaneous contractions by inhibiting spike generation on the slow wave." @default.
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- W2334387589 date "1980-01-01" @default.
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- W2334387589 title "Endogenous prostaglandins and spontaneous contractions in the circular muscle of the guinea-pig stomach." @default.
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- W2334387589 doi "https://doi.org/10.2170/jjphysiol.30.815" @default.
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