Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334411399> ?p ?o ?g. }
- W2334411399 endingPage "630" @default.
- W2334411399 startingPage "623" @default.
- W2334411399 abstract "Aberrant expression of musashi2 (MSI-2) has been detected in several malignancies. However, its role in the progression of colorectal cancer (CRC) remains unknown. Our study was designed to investigate the expression and prognostic significance of MSI-2 protein in patients with colorectal cancer. The expression of MSI-2 was detected in 164 patients’ colorectal cancer and control specimens by the tissue microarray technique and immunohistochemical staining. The correlations between MSI-2 expression and clinicopathological variables including overall survival were analyzed. The prognostic value of liver metastasis is evaluated by logistic regression and receiver operating characteristic (ROC) analysis. MSI-2 was highly expressed in 32.9% (54/164) of the colorectal cancer. Overexpression of MSI-2 was associated with depth of invasion, lymph node metastasis, distant metastasis, liver metastasis, Tumor Node Metastasis (TNM) clinical stage, and Carcinoembryonicantigen (CEA) level (P = 0.040, 0.014, <0.001, <0.001, 0.003, and 0.002, respectively). In the Cox multivariate test, MSI-2 overexpression, lymph node metastasis, and distant metastasis were found to be the independent prognostic factors (P = 0.027, 0.010, and 0.001, respectively). Further logistic regression suggested that TNM stage and MSI-2 high expression were related to liver metastasis in colorectal cancer patients. Conclusively, our study indicates that MSI-2 overexpression is associated with an unfavorable prognosis and may be a potential biomarker for liver metastasis in colorectal cancer patients." @default.
- W2334411399 created "2016-06-24" @default.
- W2334411399 creator A5018560021 @default.
- W2334411399 creator A5020852276 @default.
- W2334411399 creator A5024774792 @default.
- W2334411399 creator A5026243019 @default.
- W2334411399 creator A5051471223 @default.
- W2334411399 creator A5055072758 @default.
- W2334411399 creator A5062226078 @default.
- W2334411399 creator A5077672913 @default.
- W2334411399 creator A5078024000 @default.
- W2334411399 date "2016-01-18" @default.
- W2334411399 modified "2023-10-08" @default.
- W2334411399 title "Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer" @default.
- W2334411399 cites W1495997023 @default.
- W2334411399 cites W1607062179 @default.
- W2334411399 cites W1826852120 @default.
- W2334411399 cites W1976792842 @default.
- W2334411399 cites W1978124642 @default.
- W2334411399 cites W1980714336 @default.
- W2334411399 cites W1982289883 @default.
- W2334411399 cites W1987684058 @default.
- W2334411399 cites W1998728654 @default.
- W2334411399 cites W2011401161 @default.
- W2334411399 cites W2011472720 @default.
- W2334411399 cites W2012234882 @default.
- W2334411399 cites W2012608371 @default.
- W2334411399 cites W2013269714 @default.
- W2334411399 cites W2018657730 @default.
- W2334411399 cites W2018995141 @default.
- W2334411399 cites W2031899359 @default.
- W2334411399 cites W2032294094 @default.
- W2334411399 cites W2057647863 @default.
- W2334411399 cites W2065484467 @default.
- W2334411399 cites W2067700202 @default.
- W2334411399 cites W2071502569 @default.
- W2334411399 cites W2075542228 @default.
- W2334411399 cites W2078878537 @default.
- W2334411399 cites W2085793842 @default.
- W2334411399 cites W2086169503 @default.
- W2334411399 cites W2088116141 @default.
- W2334411399 cites W2090332105 @default.
- W2334411399 cites W2098016561 @default.
- W2334411399 cites W2106572080 @default.
- W2334411399 cites W2108074319 @default.
- W2334411399 cites W2123509170 @default.
- W2334411399 cites W2135677424 @default.
- W2334411399 cites W2149771795 @default.
- W2334411399 cites W2161817637 @default.
- W2334411399 doi "https://doi.org/10.1002/cam4.624" @default.
- W2334411399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4831280" @default.
- W2334411399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26775684" @default.
- W2334411399 hasPublicationYear "2016" @default.
- W2334411399 type Work @default.
- W2334411399 sameAs 2334411399 @default.
- W2334411399 citedByCount "27" @default.
- W2334411399 countsByYear W23344113992016 @default.
- W2334411399 countsByYear W23344113992017 @default.
- W2334411399 countsByYear W23344113992018 @default.
- W2334411399 countsByYear W23344113992019 @default.
- W2334411399 countsByYear W23344113992020 @default.
- W2334411399 countsByYear W23344113992021 @default.
- W2334411399 countsByYear W23344113992022 @default.
- W2334411399 countsByYear W23344113992023 @default.
- W2334411399 crossrefType "journal-article" @default.
- W2334411399 hasAuthorship W2334411399A5018560021 @default.
- W2334411399 hasAuthorship W2334411399A5020852276 @default.
- W2334411399 hasAuthorship W2334411399A5024774792 @default.
- W2334411399 hasAuthorship W2334411399A5026243019 @default.
- W2334411399 hasAuthorship W2334411399A5051471223 @default.
- W2334411399 hasAuthorship W2334411399A5055072758 @default.
- W2334411399 hasAuthorship W2334411399A5062226078 @default.
- W2334411399 hasAuthorship W2334411399A5077672913 @default.
- W2334411399 hasAuthorship W2334411399A5078024000 @default.
- W2334411399 hasBestOaLocation W23344113991 @default.
- W2334411399 hasConcept C104317684 @default.
- W2334411399 hasConcept C121608353 @default.
- W2334411399 hasConcept C126322002 @default.
- W2334411399 hasConcept C142724271 @default.
- W2334411399 hasConcept C143998085 @default.
- W2334411399 hasConcept C146357865 @default.
- W2334411399 hasConcept C151730666 @default.
- W2334411399 hasConcept C180754005 @default.
- W2334411399 hasConcept C193270364 @default.
- W2334411399 hasConcept C204232928 @default.
- W2334411399 hasConcept C2779013556 @default.
- W2334411399 hasConcept C2779767149 @default.
- W2334411399 hasConcept C2781197716 @default.
- W2334411399 hasConcept C502942594 @default.
- W2334411399 hasConcept C50382708 @default.
- W2334411399 hasConcept C526805850 @default.
- W2334411399 hasConcept C55493867 @default.
- W2334411399 hasConcept C61320498 @default.
- W2334411399 hasConcept C71924100 @default.
- W2334411399 hasConcept C86803240 @default.
- W2334411399 hasConceptScore W2334411399C104317684 @default.
- W2334411399 hasConceptScore W2334411399C121608353 @default.
- W2334411399 hasConceptScore W2334411399C126322002 @default.