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- W2334435193 abstract "A 73-year-old woman presented with abdominal pain radiating to the back associated with vomiting and weight loss. Blood glucose was initially normal. CT scan revealed a 2 cm tumour inthe body of the pancreas. Histopathological examination of the distal pancreatectomy specimen revealed a well differentiated neuroendocrine carcinoma with a predominantly insular and focally trabecular growth patterns. The tumour cells displayed moderate nuclear pleomorphism and coarse chromatin patterns. Up to 2 mitoses/10 HPF were observed. There was direct invasion of two adjacent lymph nodes. Immunohisto-chemically, the tumour showed positive staining for pan-neuroendo-crine markers and negative staining for glucagon, somatostatin and gastrin (insulin immunostain was not available). Ki-67 was positive in 5–6% of tumour cells. Electron microscopy revealed dense-core neurosecretory granules, many of which exhibited characteristic ‘squared-off’ crystalline forms, typically seen in beta-cell differen-tiation/insulinoma. Post-operatively, the patient developed diabetes, a known sequelae of distal pancreatectomy. Insulinomas are rare with an incidence of 2–4 patients/million population/year. They are the most common functioning pancreatic neuroendocrine tumours (NETs) and tend to occur between 40 and 60 years. Between 7% and 10% of cases are malignant. The European NET Society recently designed and approved a TNM staging proposal for foregut and pancreatic NETs, as well as suggested criteria for grading them based on mitotic count and Ki-67." @default.
- W2334435193 created "2016-06-24" @default.
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- W2334435193 date "2011-01-01" @default.
- W2334435193 modified "2023-09-25" @default.
- W2334435193 title "Well differentiated neuroendocrine carcinoma of the pancreas with ultrastructural features of insulinoma" @default.
- W2334435193 doi "https://doi.org/10.1016/s0031-3025(16)33237-8" @default.
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