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- W2334438067 abstract "Background: Angiosarcoma is a rare malignant neoplasm that usually involves the skin and subcutaneous tissue. Angiosarcoma of the gastrointestinal tract is extremely uncommon and may demonstrate multicentric epithelioid morphology. Design: We report a case of a 51-year-old male patient with disseminated epithelioid angiosarcoma (DEA) involving both small and large intestine, who presented with anemia, jaundice, melena and active lower gastrointestinal (GI) bleed since two months. The patient also gave a history of hip surgery two months back and long term analgesic abuse. Endoscopic examination of upper GIT and colon revealed erosions and actively bleeding ulcers respectively. Computed tomography (CT) arteriography revealed active contrast extravasation into proximal ileum. Emergency exploratory laparotomy revealed multiple ulcers in right colon and multiple polyps with erosions in the ileum. Surgical resection-anastomosis of the lesions were done. Histopathological and immunohistochemical assessment revealed a diagnosis of DEA. Results: On post operative day three the patient developed disseminated intravascular coagulopathy and could not be revived. Conclusions: Intestinal angiosarcoma is a diagnostic challenge because it is rare and presents with non specific symptoms. A high index of suspicion is warranted in patients presenting with multiple polyps and active GI bleeding. The appropriate classification and treatment of angiosarcomas is important as they are clinically aggressive tumors. Angiosarcomas of the gastrointestinal tract commonly display epithelioid cytomorphology, are often positive for cytokeratins and only show subtle signs of vascular differentiation, creating potential diagnostic confusion with primary or metastatic carcinoma. Immunohistochemistry with vascular markers, CK20, and S-100 protein may be helpful in differentiating angiosarcoma from carcinoma and melanoma." @default.
- W2334438067 created "2016-06-24" @default.
- W2334438067 creator A5064033129 @default.
- W2334438067 creator A5068597039 @default.
- W2334438067 date "2016-02-01" @default.
- W2334438067 modified "2023-10-18" @default.
- W2334438067 title "Disseminated epithelioid angiosarcoma presenting as multiple intestinal polyps with active bleeding" @default.
- W2334438067 doi "https://doi.org/10.1016/j.pathol.2015.12.344" @default.
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