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• W2334452934 endingPage "15" @default.
• W2334452934 startingPage "9" @default.
• W2334452934 abstract "Unmethylated CpG sequences (CpG DNA) can induce Th1 response and thus become a potential immunotherapeutic agent. A key step in the treatment is to transport CpG DNA to its receptor TLR9 located in the endocytosis pathway of target immune cells. For the effective transport, we prepared a novel complex from a β-1,3-glucan schizophyllan (SPG) and CpG DNA, and administered the complex to murine peritoneal macrophages that had been previously activated by thioglycollate and expressed a major β-1,3-glucan receptor Dectin-1 on the cellular surface. Flow cytometric analysis and microscopic observation showed that the complex was taken up by the macrophage through Dectin-1 mediated pathway. Indeed, ELISA demonstrated that IL-12 production was increased sigmoidally with increasing SPG/CpG DNA ratio in the complexation, and reached the maximum at the SPG-rich composition. In the present work, we describe a new approach to deliver CpG DNA to immune cells by use of a β-1,3-glucan/DNA complex." @default.
• W2334452934 created "2016-06-24" @default.
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• W2334452934 creator A5076929039 @default.
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• W2334452934 date "2010-12-02" @default.
• W2334452934 modified "2023-09-30" @default.
• W2334452934 title "Enhanced Cytokine Secretion from Primary Macrophages due to Dectin-1 Mediated Uptake of CpG DNA/β-1,3-Glucan Complex" @default.
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• W2334452934 doi "https://doi.org/10.1021/bc1001196" @default.
• W2334452934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21126031" @default.
• W2334452934 hasPublicationYear "2010" @default.
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