Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334457559> ?p ?o ?g. }
- W2334457559 endingPage "725" @default.
- W2334457559 startingPage "713" @default.
- W2334457559 abstract "Lactate dehydrogenase (LDH) inhibition is considered a worthwhile attempt in the development of innovative anticancer strategies. Unfortunately, in spite of the involvement of several research institutions and pharma-companies, the discovery of LDH inhibitors with drug-like properties seems a hardly resolvable challenge. While awaiting new advancements, in the present review we will examine other pathologic conditions characterized by increased glycolysis and LDH activity, which could potentially benefit from LDH inhibition. The rationale for targeting LDH activity in these contexts is the same justifying the LDH-based approach in anticancer therapy: because of the enzyme position at the end of glycolytic pathway, LDH inhibitors are not expected to hinder glucose metabolism of normal cells. Moreover, we will summarize the latest contributions in the discovery of enzyme inhibitors and try to glance over the reasons underlying the complexity of this research." @default.
- W2334457559 created "2016-06-24" @default.
- W2334457559 creator A5034606821 @default.
- W2334457559 creator A5072304302 @default.
- W2334457559 creator A5084233509 @default.
- W2334457559 creator A5086329073 @default.
- W2334457559 date "2016-04-01" @default.
- W2334457559 modified "2023-10-03" @default.
- W2334457559 title "Lactate dehydrogenase inhibition: exploring possible applications beyond cancer treatment" @default.
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