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- W2334460495 abstract "Septic shock is the most common cause of death in intensive care units due to an aggressive inflammatory response that leads to multiple organ failure. However, a lipopolysaccharide (LPS) tolerance phenomenon (a nonreaction to LPS), is also often described. Neither the inflammatory response nor the tolerance is completely understood. In this work, both of these responses were analyzed using microarrays in zebrafish. Fish that were 4 or 6 days postfertilization (dpf) and received a lethal dose (LD) of LPS exhibited 100% mortality in a few days. Their transcriptome profile, even at 4 dpf, resembled the profile in humans with severe sepsis. Moreover, we selected 4-dpf fish to set up a tolerance protocol: fish treated with a nonlethal concentration of Escherichia coli LPS exhibited complete protection against the LD of LPS. Most of the main inflammatory molecules described in mammals were represented in the zebrafish microarray experiments. Additionally and focusing on this tolerance response, the use of cyclodextrins may mobilize cholesterol reservoirs to decrease mortality after a LD dose of LPS. Therefore, it is possible that the use of the whole animal could provide some clues to enhance the understanding of the inflammatory/tolerance response and to guide drug discovery." @default.
- W2334460495 created "2016-06-24" @default.
- W2334460495 creator A5006562505 @default.
- W2334460495 creator A5035725666 @default.
- W2334460495 creator A5059682637 @default.
- W2334460495 creator A5061485833 @default.
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- W2334460495 creator A5081019807 @default.
- W2334460495 creator A5081743914 @default.
- W2334460495 creator A5082578354 @default.
- W2334460495 date "2014-10-01" @default.
- W2334460495 modified "2023-10-17" @default.
- W2334460495 title "The Involvement of Cholesterol in Sepsis and Tolerance to Lipopolysaccharide Highlighted by the Transcriptome Analysis of Zebrafish (<i>Danio rerio</i>)" @default.
- W2334460495 cites W1534586188 @default.
- W2334460495 cites W1544923801 @default.
- W2334460495 cites W1564861448 @default.
- W2334460495 cites W1645795322 @default.
- W2334460495 cites W1828093076 @default.
- W2334460495 cites W1857336351 @default.
- W2334460495 cites W1899610218 @default.
- W2334460495 cites W1925840058 @default.
- W2334460495 cites W1953329867 @default.
- W2334460495 cites W1969185924 @default.
- W2334460495 cites W1969449483 @default.
- W2334460495 cites W1976521535 @default.
- W2334460495 cites W1977426928 @default.
- W2334460495 cites W1978541724 @default.
- W2334460495 cites W1990394752 @default.
- W2334460495 cites W1990484548 @default.
- W2334460495 cites W1990632702 @default.
- W2334460495 cites W1992446264 @default.
- W2334460495 cites W1998477311 @default.
- W2334460495 cites W1999987242 @default.
- W2334460495 cites W2002444829 @default.
- W2334460495 cites W2003483275 @default.
- W2334460495 cites W2005406125 @default.
- W2334460495 cites W2013056431 @default.
- W2334460495 cites W2013826174 @default.
- W2334460495 cites W2016000281 @default.
- W2334460495 cites W2016095013 @default.
- W2334460495 cites W2020179710 @default.
- W2334460495 cites W2020342012 @default.
- W2334460495 cites W2022422039 @default.
- W2334460495 cites W2031648179 @default.
- W2334460495 cites W2037533969 @default.
- W2334460495 cites W2038363528 @default.
- W2334460495 cites W2039675935 @default.
- W2334460495 cites W2040530527 @default.
- W2334460495 cites W2045444884 @default.
- W2334460495 cites W2048630989 @default.
- W2334460495 cites W2054159498 @default.
- W2334460495 cites W2054553613 @default.
- W2334460495 cites W2055146071 @default.
- W2334460495 cites W2056700771 @default.
- W2334460495 cites W2057257335 @default.
- W2334460495 cites W2058270691 @default.
- W2334460495 cites W2062715867 @default.
- W2334460495 cites W2064623889 @default.
- W2334460495 cites W2069686651 @default.
- W2334460495 cites W2070040136 @default.
- W2334460495 cites W2071228946 @default.
- W2334460495 cites W2075079792 @default.
- W2334460495 cites W2076357832 @default.
- W2334460495 cites W2078330541 @default.
- W2334460495 cites W2092591554 @default.
- W2334460495 cites W2098643925 @default.
- W2334460495 cites W2100363461 @default.
- W2334460495 cites W2102899871 @default.
- W2334460495 cites W2104942758 @default.
- W2334460495 cites W2105135885 @default.
- W2334460495 cites W2107881603 @default.
- W2334460495 cites W2108244474 @default.
- W2334460495 cites W2109765271 @default.
- W2334460495 cites W2109841438 @default.
- W2334460495 cites W2110814372 @default.
- W2334460495 cites W2111395080 @default.
- W2334460495 cites W2111548425 @default.
- W2334460495 cites W2113740320 @default.
- W2334460495 cites W2122708604 @default.
- W2334460495 cites W2132034930 @default.
- W2334460495 cites W2132206417 @default.
- W2334460495 cites W2133691474 @default.
- W2334460495 cites W2135148910 @default.
- W2334460495 cites W2135598498 @default.
- W2334460495 cites W2136746152 @default.
- W2334460495 cites W2137082708 @default.
- W2334460495 cites W2137083667 @default.
- W2334460495 cites W2137450484 @default.
- W2334460495 cites W2140605886 @default.
- W2334460495 cites W2141226820 @default.
- W2334460495 cites W2143392718 @default.
- W2334460495 cites W2143918856 @default.
- W2334460495 cites W2144830469 @default.
- W2334460495 cites W2152578678 @default.
- W2334460495 cites W2155142785 @default.
- W2334460495 cites W2157282632 @default.
- W2334460495 cites W2159724945 @default.