FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334475149> ?p ?o ?g. }

• W2334475149 endingPage "3527" @default.
• W2334475149 startingPage "3515" @default.
• W2334475149 abstract "RNA interference has emerged as a powerful strategy in cancer therapy because it allows silencing of specific genes associated with tumor progression and resistance. Mad2 is an essential mitotic checkpoint component required for accurate chromosome segregation during mitosis, and its complete abolition leads to cell death. We have developed an epidermal growth factor receptor (EGFR)-targeted chitosan system for silencing the Mad2 gene as a strategy to efficiently induce cell death in EGFR overexpressing human A549 non-small cell lung cancer cells. Control and EGFR-targeted chitosan nanoparticles loaded with small interfering RNAs (siRNAs) against Mad2 were formulated and characterized for size, charge, morphology, and encapsulation efficiency. Qualitative and quantitative intracellular uptake studies by confocal imaging and flow cytometry, respectively, showed time-dependent enhanced and selective intracellular internalization of EGFR-targeted nanoparticles compared to nontargeted system. Targeted nanoparticles showed nearly complete depletion of Mad2 expression in A549 cells contrasting with the partial depletion in the nontargeted system. Accordingly, Mad2-silencing-induced apoptotic cell death was confirmed by cytotoxicity assay and flow cytometry. Our results demonstrate that EGFR-targeted chitosan loaded with Mad2 siRNAs is a potent delivery system for selective killing of cancer cells." @default.
• W2334475149 created "2016-06-24" @default.
• W2334475149 creator A5009363014 @default.
• W2334475149 creator A5019215930 @default.
• W2334475149 creator A5041458969 @default.
• W2334475149 creator A5041950062 @default.
• W2334475149 creator A5064469636 @default.
• W2334475149 creator A5067909461 @default.
• W2334475149 date "2014-09-26" @default.
• W2334475149 modified "2023-10-18" @default.
• W2334475149 title "<i>Mad2</i> Checkpoint Gene Silencing Using Epidermal Growth Factor Receptor-Targeted Chitosan Nanoparticles in Non-Small Cell Lung Cancer Model" @default.
• W2334475149 cites W1488719611 @default.
• W2334475149 cites W1503825257 @default.
• W2334475149 cites W1512138795 @default.
• W2334475149 cites W1554880727 @default.
• W2334475149 cites W1971886874 @default.
• W2334475149 cites W1973345865 @default.
• W2334475149 cites W1975813586 @default.
• W2334475149 cites W1976060898 @default.
• W2334475149 cites W1980253057 @default.
• W2334475149 cites W1980435339 @default.
• W2334475149 cites W1994986226 @default.
• W2334475149 cites W1999327728 @default.
• W2334475149 cites W1999605403 @default.
• W2334475149 cites W2006539176 @default.
• W2334475149 cites W2013091589 @default.
• W2334475149 cites W2018731076 @default.
• W2334475149 cites W2019267098 @default.
• W2334475149 cites W2026881684 @default.
• W2334475149 cites W2027385673 @default.
• W2334475149 cites W2027891004 @default.
• W2334475149 cites W2030202463 @default.
• W2334475149 cites W2032639718 @default.
• W2334475149 cites W2036075451 @default.
• W2334475149 cites W2036903274 @default.
• W2334475149 cites W2041665769 @default.
• W2334475149 cites W2056966258 @default.
• W2334475149 cites W2057488004 @default.
• W2334475149 cites W2059640573 @default.
• W2334475149 cites W2064434715 @default.
• W2334475149 cites W2065240254 @default.
• W2334475149 cites W2069336962 @default.
• W2334475149 cites W2071187512 @default.
• W2334475149 cites W2072823827 @default.
• W2334475149 cites W2077815337 @default.
• W2334475149 cites W2081477031 @default.
• W2334475149 cites W2083960630 @default.
• W2334475149 cites W2084314276 @default.
• W2334475149 cites W2086971982 @default.
• W2334475149 cites W2087641414 @default.
• W2334475149 cites W2088849426 @default.
• W2334475149 cites W2093945871 @default.
• W2334475149 cites W2094788147 @default.
• W2334475149 cites W2098337093 @default.
• W2334475149 cites W2107969198 @default.
• W2334475149 cites W2108872387 @default.
• W2334475149 cites W2119775441 @default.
• W2334475149 cites W2127685088 @default.
• W2334475149 cites W2140731073 @default.
• W2334475149 cites W2150702593 @default.
• W2334475149 cites W2160272852 @default.
• W2334475149 cites W2163482611 @default.
• W2334475149 cites W2166698742 @default.
• W2334475149 cites W2168479321 @default.
• W2334475149 cites W4231299886 @default.
• W2334475149 doi "https://doi.org/10.1021/mp5002894" @default.
• W2334475149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4186685" @default.
• W2334475149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25256346" @default.
• W2334475149 hasPublicationYear "2014" @default.
• W2334475149 type Work @default.
• W2334475149 sameAs 2334475149 @default.
• W2334475149 citedByCount "53" @default.
• W2334475149 countsByYear W23344751492015 @default.
• W2334475149 countsByYear W23344751492016 @default.
• W2334475149 countsByYear W23344751492017 @default.
• W2334475149 countsByYear W23344751492018 @default.
• W2334475149 countsByYear W23344751492019 @default.
• W2334475149 countsByYear W23344751492020 @default.
• W2334475149 countsByYear W23344751492021 @default.
• W2334475149 countsByYear W23344751492022 @default.
• W2334475149 countsByYear W23344751492023 @default.
• W2334475149 crossrefType "journal-article" @default.
• W2334475149 hasAuthorship W2334475149A5009363014 @default.
• W2334475149 hasAuthorship W2334475149A5019215930 @default.
• W2334475149 hasAuthorship W2334475149A5041458969 @default.
• W2334475149 hasAuthorship W2334475149A5041950062 @default.
• W2334475149 hasAuthorship W2334475149A5064469636 @default.
• W2334475149 hasAuthorship W2334475149A5067909461 @default.
• W2334475149 hasBestOaLocation W23344751491 @default.
• W2334475149 hasConcept C104317684 @default.
• W2334475149 hasConcept C105696609 @default.
• W2334475149 hasConcept C119056186 @default.
• W2334475149 hasConcept C121608353 @default.
• W2334475149 hasConcept C1491633281 @default.
• W2334475149 hasConcept C153911025 @default.
• W2334475149 hasConcept C185592680 @default.
• W2334475149 hasConcept C22615655 @default.
• W2334475149 hasConcept C2776362946 @default.

• next