Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334516635> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2334516635 abstract "The natural fluorescence (autofluorescence) of tissues has been noted as a biomarker for cancer for several decades. Autofluorescence contrast between tumors and healthy tissues has been of significant interest in endoscopy, leading to development of autofluorescence endoscopes capable of visualizing 2-3 fluorescence emission wavelengths to achieve maximal contrast. However, tumor detection with autofluorescence endoscopes is hindered by low fluorescence signal and limited quantitative information, resulting in prolonged endoscopic procedures, prohibitive acquisition times, and reduced specificity of detection. Our lab has designed a novel excitation-scanning hyperspectral imaging system with high fluorescence signal detection, low acquisition time, and enhanced spectral discrimination. In this study, we surveyed a comprehensive set of excised tissues to assess the feasibility of detecting tissue-specific pathologies using excitation-scanning. Fresh, untreated tissue specimens were imaged from 360 to 550 nm on an inverted fluorescence microscope equipped with a set of thin-film tunable filters (Semrock, A Unit of IDEX). Images were subdivided into training and test sets. Automated endmember extraction (ENVI 5.1, Exelis) with PCA identified endmembers within training images of autofluorescence. A spectral library was created from 9 endmembers. The library was used for identification of endmembers in test images. Our results suggest (1) spectral differentiation of multiple tissue types is possible using excitation scanning; (2) shared spectra between tissue types; and (3) the ability to identify unique morphological features in disparate tissues from shared autofluorescent components. Future work will focus on isolating specific molecular signatures present in tissue spectra, and elucidating the contribution of these signatures in pathologies." @default.
- W2334516635 created "2016-06-24" @default.
- W2334516635 creator A5014144990 @default.
- W2334516635 creator A5032098701 @default.
- W2334516635 creator A5036136012 @default.
- W2334516635 creator A5051653179 @default.
- W2334516635 creator A5076121658 @default.
- W2334516635 date "2016-04-06" @default.
- W2334516635 modified "2023-10-03" @default.
- W2334516635 title "Feasibility for detection of autofluorescent signatures in rat organs using a novel excitation-scanning hyperspectral imaging system" @default.
- W2334516635 cites W1482574696 @default.
- W2334516635 cites W1603972224 @default.
- W2334516635 cites W1980467097 @default.
- W2334516635 cites W2015266660 @default.
- W2334516635 cites W2041632368 @default.
- W2334516635 cites W2042692078 @default.
- W2334516635 cites W2065426452 @default.
- W2334516635 cites W2080686462 @default.
- W2334516635 cites W2100955622 @default.
- W2334516635 cites W2129827453 @default.
- W2334516635 cites W2168799073 @default.
- W2334516635 cites W4233427285 @default.
- W2334516635 cites W4253883548 @default.
- W2334516635 cites W4255137887 @default.
- W2334516635 doi "https://doi.org/10.1117/12.2213214" @default.
- W2334516635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8203318" @default.
- W2334516635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34131358" @default.
- W2334516635 hasPublicationYear "2016" @default.
- W2334516635 type Work @default.
- W2334516635 sameAs 2334516635 @default.
- W2334516635 citedByCount "3" @default.
- W2334516635 countsByYear W23345166352018 @default.
- W2334516635 countsByYear W23345166352020 @default.
- W2334516635 crossrefType "proceedings-article" @default.
- W2334516635 hasAuthorship W2334516635A5014144990 @default.
- W2334516635 hasAuthorship W2334516635A5032098701 @default.
- W2334516635 hasAuthorship W2334516635A5036136012 @default.
- W2334516635 hasAuthorship W2334516635A5051653179 @default.
- W2334516635 hasAuthorship W2334516635A5076121658 @default.
- W2334516635 hasBestOaLocation W23345166352 @default.
- W2334516635 hasConcept C120665830 @default.
- W2334516635 hasConcept C121332964 @default.
- W2334516635 hasConcept C127313418 @default.
- W2334516635 hasConcept C136229726 @default.
- W2334516635 hasConcept C142724271 @default.
- W2334516635 hasConcept C147080431 @default.
- W2334516635 hasConcept C154945302 @default.
- W2334516635 hasConcept C159078339 @default.
- W2334516635 hasConcept C176641082 @default.
- W2334516635 hasConcept C179687394 @default.
- W2334516635 hasConcept C192562407 @default.
- W2334516635 hasConcept C2993001476 @default.
- W2334516635 hasConcept C3232514 @default.
- W2334516635 hasConcept C41008148 @default.
- W2334516635 hasConcept C57477423 @default.
- W2334516635 hasConcept C62649853 @default.
- W2334516635 hasConcept C71924100 @default.
- W2334516635 hasConcept C91881484 @default.
- W2334516635 hasConceptScore W2334516635C120665830 @default.
- W2334516635 hasConceptScore W2334516635C121332964 @default.
- W2334516635 hasConceptScore W2334516635C127313418 @default.
- W2334516635 hasConceptScore W2334516635C136229726 @default.
- W2334516635 hasConceptScore W2334516635C142724271 @default.
- W2334516635 hasConceptScore W2334516635C147080431 @default.
- W2334516635 hasConceptScore W2334516635C154945302 @default.
- W2334516635 hasConceptScore W2334516635C159078339 @default.
- W2334516635 hasConceptScore W2334516635C176641082 @default.
- W2334516635 hasConceptScore W2334516635C179687394 @default.
- W2334516635 hasConceptScore W2334516635C192562407 @default.
- W2334516635 hasConceptScore W2334516635C2993001476 @default.
- W2334516635 hasConceptScore W2334516635C3232514 @default.
- W2334516635 hasConceptScore W2334516635C41008148 @default.
- W2334516635 hasConceptScore W2334516635C57477423 @default.
- W2334516635 hasConceptScore W2334516635C62649853 @default.
- W2334516635 hasConceptScore W2334516635C71924100 @default.
- W2334516635 hasConceptScore W2334516635C91881484 @default.
- W2334516635 hasLocation W23345166351 @default.
- W2334516635 hasLocation W23345166352 @default.
- W2334516635 hasOpenAccess W2334516635 @default.
- W2334516635 hasPrimaryLocation W23345166351 @default.
- W2334516635 hasRelatedWork W1537873589 @default.
- W2334516635 hasRelatedWork W2007543402 @default.
- W2334516635 hasRelatedWork W2089076201 @default.
- W2334516635 hasRelatedWork W2579424881 @default.
- W2334516635 hasRelatedWork W2992361169 @default.
- W2334516635 hasRelatedWork W3007636191 @default.
- W2334516635 hasRelatedWork W3111461452 @default.
- W2334516635 hasRelatedWork W3134642825 @default.
- W2334516635 hasRelatedWork W4241546789 @default.
- W2334516635 hasRelatedWork W4306409707 @default.
- W2334516635 isParatext "false" @default.
- W2334516635 isRetracted "false" @default.
- W2334516635 magId "2334516635" @default.
- W2334516635 workType "article" @default.