FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334577103> ?p ?o ?g. }

• W2334577103 endingPage "6814" @default.
• W2334577103 startingPage "6806" @default.
• W2334577103 abstract "Thermodynamic parameters for the insertion and self-association of transmembrane helices are important for understanding the folding of helical membrane proteins. The lipid composition of bilayers would significantly affect these fundamental processes, although how is not well understood. Experimental systems using model transmembrane helices and lipid bilayers are useful for measuring and interpreting thermodynamic parameters (ΔG, ΔH, ΔS, and ΔCp) for the processes. In this study, the effect of the charge, phase, acyl chain unsaturation, and lateral pressure profile of bilayers on the membrane partitioning of the transmembrane helix (AALALAA)3 was examined. Furthermore, the effect of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylethanolamine (POPE) on the thermodynamics for insertion and self-association of the helix in host membranes composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) was investigated in detail. Interbilayer transfer of the helix monomer from POPC to POPC/POPE (1/1) bilayers was unfavorable (ΔG = +4.5 ± 2.9 kJ mol–1 at 35 °C) due to an increase in enthalpy (ΔH = +31.1 ± 2.1 kJ mol–1). On the other hand, antiparallel dimerization of the helices in POPC/POPE (1/1) bilayers was enhanced compared with that in POPC bilayers (ΔΔG = −4.9 ± 0.2 kJ mol–1 at 35 °C) due to a decrease in enthalpy (ΔΔH = −33.2 ± 1.5 kJ mol–1). A greater thickness of POPC/POPE bilayers only partially explained the observed effects. The residual effects could be related to changes in other physical properties such as higher lateral pressure in the hydrocarbon core in the PE-containing membrane. The origin of the enthalpy-driven “lipophobic” force that modulates the insertion and association of transmembrane helices will be discussed." @default.
• W2334577103 created "2016-06-24" @default.
• W2334577103 creator A5012808950 @default.
• W2334577103 creator A5072599390 @default.
• W2334577103 creator A5079745740 @default.
• W2334577103 creator A5083344330 @default.
• W2334577103 date "2011-07-21" @default.
• W2334577103 modified "2023-10-12" @default.
• W2334577103 title "Thermodynamics of Insertion and Self-Association of a Transmembrane Helix: A Lipophobic Interaction by Phosphatidylethanolamine" @default.
• W2334577103 cites W1513897103 @default.
• W2334577103 cites W1963722000 @default.
• W2334577103 cites W1966170819 @default.
• W2334577103 cites W1968028474 @default.
• W2334577103 cites W1973687920 @default.
• W2334577103 cites W1975670427 @default.
• W2334577103 cites W1977157146 @default.
• W2334577103 cites W1986410640 @default.
• W2334577103 cites W1986470510 @default.
• W2334577103 cites W1989808058 @default.
• W2334577103 cites W1996478334 @default.
• W2334577103 cites W1996795941 @default.
• W2334577103 cites W1997501696 @default.
• W2334577103 cites W2000179170 @default.
• W2334577103 cites W2000729091 @default.
• W2334577103 cites W2001106464 @default.
• W2334577103 cites W2003507857 @default.
• W2334577103 cites W2007402446 @default.
• W2334577103 cites W2008846230 @default.
• W2334577103 cites W2013407749 @default.
• W2334577103 cites W2015524253 @default.
• W2334577103 cites W2016343967 @default.
• W2334577103 cites W2017074521 @default.
• W2334577103 cites W2021706112 @default.
• W2334577103 cites W2035469122 @default.
• W2334577103 cites W2045155470 @default.
• W2334577103 cites W2052002053 @default.
• W2334577103 cites W2060878281 @default.
• W2334577103 cites W2067577824 @default.
• W2334577103 cites W2069966083 @default.
• W2334577103 cites W2073726493 @default.
• W2334577103 cites W2078995260 @default.
• W2334577103 cites W2080226598 @default.
• W2334577103 cites W2082148481 @default.
• W2334577103 cites W2103730192 @default.
• W2334577103 cites W2110884380 @default.
• W2334577103 cites W2115252051 @default.
• W2334577103 cites W2118798045 @default.
• W2334577103 cites W2124329888 @default.
• W2334577103 cites W2146752518 @default.
• W2334577103 cites W2147691794 @default.
• W2334577103 cites W2149026054 @default.
• W2334577103 cites W2155147384 @default.
• W2334577103 cites W2157542919 @default.
• W2334577103 cites W2163025802 @default.
• W2334577103 cites W4245084385 @default.
• W2334577103 doi "https://doi.org/10.1021/bi200560c" @default.
• W2334577103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21749146" @default.
• W2334577103 hasPublicationYear "2011" @default.
• W2334577103 type Work @default.
• W2334577103 sameAs 2334577103 @default.
• W2334577103 citedByCount "17" @default.
• W2334577103 countsByYear W23345771032012 @default.
• W2334577103 countsByYear W23345771032013 @default.
• W2334577103 countsByYear W23345771032014 @default.
• W2334577103 countsByYear W23345771032015 @default.
• W2334577103 countsByYear W23345771032016 @default.
• W2334577103 countsByYear W23345771032017 @default.
• W2334577103 countsByYear W23345771032018 @default.
• W2334577103 countsByYear W23345771032020 @default.
• W2334577103 countsByYear W23345771032021 @default.
• W2334577103 countsByYear W23345771032022 @default.
• W2334577103 countsByYear W23345771032023 @default.
• W2334577103 crossrefType "journal-article" @default.
• W2334577103 hasAuthorship W2334577103A5012808950 @default.
• W2334577103 hasAuthorship W2334577103A5072599390 @default.
• W2334577103 hasAuthorship W2334577103A5079745740 @default.
• W2334577103 hasAuthorship W2334577103A5083344330 @default.
• W2334577103 hasConcept C118892022 @default.
• W2334577103 hasConcept C121332964 @default.
• W2334577103 hasConcept C170493617 @default.
• W2334577103 hasConcept C185592680 @default.
• W2334577103 hasConcept C18903297 @default.
• W2334577103 hasConcept C192157962 @default.
• W2334577103 hasConcept C24530287 @default.
• W2334577103 hasConcept C2778530040 @default.
• W2334577103 hasConcept C2779965526 @default.
• W2334577103 hasConcept C2780943371 @default.
• W2334577103 hasConcept C3288061 @default.
• W2334577103 hasConcept C39944091 @default.
• W2334577103 hasConcept C41625074 @default.
• W2334577103 hasConcept C55493867 @default.
• W2334577103 hasConcept C8010536 @default.
• W2334577103 hasConcept C86803240 @default.
• W2334577103 hasConcept C97355855 @default.
• W2334577103 hasConceptScore W2334577103C118892022 @default.
• W2334577103 hasConceptScore W2334577103C121332964 @default.
• W2334577103 hasConceptScore W2334577103C170493617 @default.
• W2334577103 hasConceptScore W2334577103C185592680 @default.

• next