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- W2334626778 abstract "During the process of reprogramming to induced pluripotent stem (iPS) cells, somatic cells switch from oxidative to glycolytic metabolism, a transition associated with profound mitochondrial reorganization. Neither the importance of mitochondrial remodelling for cell reprogramming, nor the molecular mechanisms controlling this process are well understood. Here, we show that an early wave of mitochondrial fragmentation occurs upon expression of reprogramming factors. Reprogramming-induced mitochondrial fission is associated with a minor decrease in mitochondrial mass but not with mitophagy. The pro-fission factor Drp1 is phosphorylated early in reprogramming, and its knockdown and inhibition impairs both mitochondrial fragmentation and generation of iPS cell colonies. Drp1 phosphorylation depends on Erk activation in early reprogramming, which occurs, at least in part, due to downregulation of the MAP kinase phosphatase Dusp6. Taken together, our data indicate that mitochondrial fission controlled by an Erk-Drp1 axis constitutes an early and necessary step in the reprogramming process to pluripotency." @default.
- W2334626778 created "2016-06-24" @default.
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- W2334626778 date "2016-03-31" @default.
- W2334626778 modified "2023-10-11" @default.
- W2334626778 title "Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming" @default.
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- W2334626778 doi "https://doi.org/10.1038/ncomms11124" @default.
- W2334626778 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4821885" @default.
- W2334626778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27030341" @default.
- W2334626778 hasPublicationYear "2016" @default.
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