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- W2334647415 abstract "Self-rated health is often viewed as a relatively stable construct and few studies have investigated short-term variations or used experimental approaches to manipulate subjective health perception. We have previously showed that higher levels of inflammatory cytokines are generally connected with less favorable self-rated health. Therefore, we explored the subjective health experience in response to a canonical activation of an inflammatory response with endotoxin in healthy subjects. In a first study, eight healthy participants were injected at two occasions: once with 0.8 ng/kg lipopolysaccharide (LPS) and once with placebo. In a second study, a between-subject design was used where 51 healthy subjects were injected with either LPS (now reduced to 0.6 ng/kg) or placebo. Stimulation resulted in a peak response in pro-inflammatory cytokines after 90–120 min. Ninety minutes after injection, perceived health framed to represent the present day (“How is your health right now?”), was significantly lowered in the endotoxin condition in both studies ( p ’s p ’s" @default.
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- W2334647415 date "2012-09-01" @default.
- W2334647415 modified "2023-10-01" @default.
- W2334647415 title "171. Self-rated health in response to experimental manipulations of inflammation" @default.
- W2334647415 doi "https://doi.org/10.1016/j.bbi.2012.07.195" @default.
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