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• W2334652718 abstract "Introduction Monosodium glutamate (MSG) is a substance that is widely used as flavoring agent. It is added to a broad range of food categories with no limit, although it has been reported to have toxic effects on different organs. Aim The aim of this study was to investigate the histological and immunohistochemical effects of MSG on the fallopian tube of adult albino rats and to study the possible protective role of vitamin C supplementation. Materials and methods Thirty adult female albino rats were used in this study. They were divided into three groups: control, treated, and supplemented. The control group received fixed amount of Grower’s marsh without MSG daily for 14 days. The MSG-treated group was given 6 g of MSG thoroughly mixed with equal amount of feed (Grower’s marsh) daily for 14 days. The vitamin C-supplemented group received 250 mg/kg of vitamin C through an orogastric tube in concomitant with the same dose of MSG as in the treated group. At the time of sacrifice, the fallopian tubes were dissected and processed for histological and immunohistochemical studies for inducible nitric oxide synthase. Results The fallopian tubes of rats from the MSG-treated group showed some cellular hypertrophy of the columnar epithelium and distortion of the basement membrane. There were degenerative changes observed in some parts. Exfoliated cells in the lumen and marked vacuolations in the stromal cells were seen. There was a significant increase in the area percentage of collagen fibers and a significant increase in the optical density of inducible nitric oxide synthase reaction in the treated group compared with the control group. In the vitamin C-supplemented group, there was improvement in the histological and immunohistochemical changes. Conclusion Administration of MSG induces a degenerative effect on the fallopian tubes of adult rats, confirmed through the histological and immunohistochemical changes. However, vitamin C can improve these induced changes through its antioxidant effects." @default.
• W2334652718 created "2016-06-24" @default.
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• W2334652718 date "2015-03-01" @default.
• W2334652718 modified "2023-09-24" @default.
• W2334652718 title "Effect of monosodium glutamate on the fallopian tubes of adult albino rats and the possible protective role of vitamin C" @default.
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• W2334652718 doi "https://doi.org/10.1097/01.ehx.0000459830.75073.36" @default.
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