Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334654004> ?p ?o ?g. }
- W2334654004 endingPage "542" @default.
- W2334654004 startingPage "537" @default.
- W2334654004 abstract "A main challenge in the development of new agents for the treatment of Pseudomonas aeruginosa infections is the identification of chemotypes that efficiently penetrate the cell envelope and are not susceptible to established resistance mechanisms. Siderophore-conjugated monocarbams are attractive because of their ability to hijack the bacteria's iron uptake machinery for transport into the periplasm and their inherent stability to metallo-β-lactamases. Through development of the SAR we identified a number of modifications to the scaffold that afforded active anti-P. aeruginosa agents with good physicochemical properties. Through crystallographic efforts we gained a better understanding into how these compounds bind to the target penicillin binding protein PBP3 and factors to consider for future design." @default.
- W2334654004 created "2016-06-24" @default.
- W2334654004 creator A5000876897 @default.
- W2334654004 creator A5003079010 @default.
- W2334654004 creator A5011552423 @default.
- W2334654004 creator A5018857400 @default.
- W2334654004 creator A5019513616 @default.
- W2334654004 creator A5028497295 @default.
- W2334654004 creator A5032105877 @default.
- W2334654004 creator A5037050717 @default.
- W2334654004 creator A5044352209 @default.
- W2334654004 creator A5052925180 @default.
- W2334654004 creator A5056061775 @default.
- W2334654004 creator A5063029522 @default.
- W2334654004 creator A5065356202 @default.
- W2334654004 creator A5069546676 @default.
- W2334654004 creator A5073175651 @default.
- W2334654004 creator A5080826068 @default.
- W2334654004 date "2015-03-30" @default.
- W2334654004 modified "2023-10-07" @default.
- W2334654004 title "SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of <i>Pseudomonas aeruginosa</i> PBP3" @default.
- W2334654004 cites W1972122276 @default.
- W2334654004 cites W1987635163 @default.
- W2334654004 cites W1995987590 @default.
- W2334654004 cites W1997083763 @default.
- W2334654004 cites W2003104921 @default.
- W2334654004 cites W2016831884 @default.
- W2334654004 cites W2032559812 @default.
- W2334654004 cites W2037689899 @default.
- W2334654004 cites W2038044331 @default.
- W2334654004 cites W2050970821 @default.
- W2334654004 cites W2072684642 @default.
- W2334654004 cites W2080927615 @default.
- W2334654004 cites W2084710823 @default.
- W2334654004 cites W2090450331 @default.
- W2334654004 cites W2102906662 @default.
- W2334654004 cites W2105689594 @default.
- W2334654004 cites W2131171455 @default.
- W2334654004 cites W2139516496 @default.
- W2334654004 cites W2142692636 @default.
- W2334654004 cites W2148423298 @default.
- W2334654004 cites W2149198421 @default.
- W2334654004 cites W2153887116 @default.
- W2334654004 cites W2165923378 @default.
- W2334654004 cites W2168747862 @default.
- W2334654004 cites W2169641796 @default.
- W2334654004 cites W2171739737 @default.
- W2334654004 cites W2313930627 @default.
- W2334654004 cites W2331479060 @default.
- W2334654004 cites W2332504278 @default.
- W2334654004 doi "https://doi.org/10.1021/acsmedchemlett.5b00026" @default.
- W2334654004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4434466" @default.
- W2334654004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26005529" @default.
- W2334654004 hasPublicationYear "2015" @default.
- W2334654004 type Work @default.
- W2334654004 sameAs 2334654004 @default.
- W2334654004 citedByCount "16" @default.
- W2334654004 countsByYear W23346540042016 @default.
- W2334654004 countsByYear W23346540042017 @default.
- W2334654004 countsByYear W23346540042018 @default.
- W2334654004 countsByYear W23346540042019 @default.
- W2334654004 countsByYear W23346540042020 @default.
- W2334654004 countsByYear W23346540042021 @default.
- W2334654004 countsByYear W23346540042022 @default.
- W2334654004 countsByYear W23346540042023 @default.
- W2334654004 crossrefType "journal-article" @default.
- W2334654004 hasAuthorship W2334654004A5000876897 @default.
- W2334654004 hasAuthorship W2334654004A5003079010 @default.
- W2334654004 hasAuthorship W2334654004A5011552423 @default.
- W2334654004 hasAuthorship W2334654004A5018857400 @default.
- W2334654004 hasAuthorship W2334654004A5019513616 @default.
- W2334654004 hasAuthorship W2334654004A5028497295 @default.
- W2334654004 hasAuthorship W2334654004A5032105877 @default.
- W2334654004 hasAuthorship W2334654004A5037050717 @default.
- W2334654004 hasAuthorship W2334654004A5044352209 @default.
- W2334654004 hasAuthorship W2334654004A5052925180 @default.
- W2334654004 hasAuthorship W2334654004A5056061775 @default.
- W2334654004 hasAuthorship W2334654004A5063029522 @default.
- W2334654004 hasAuthorship W2334654004A5065356202 @default.
- W2334654004 hasAuthorship W2334654004A5069546676 @default.
- W2334654004 hasAuthorship W2334654004A5073175651 @default.
- W2334654004 hasAuthorship W2334654004A5080826068 @default.
- W2334654004 hasBestOaLocation W23346540042 @default.
- W2334654004 hasConcept C104317684 @default.
- W2334654004 hasConcept C108319773 @default.
- W2334654004 hasConcept C112613896 @default.
- W2334654004 hasConcept C174802600 @default.
- W2334654004 hasConcept C178790620 @default.
- W2334654004 hasConcept C185592680 @default.
- W2334654004 hasConcept C201663137 @default.
- W2334654004 hasConcept C21951064 @default.
- W2334654004 hasConcept C2776653525 @default.
- W2334654004 hasConcept C2777637488 @default.
- W2334654004 hasConcept C501593827 @default.
- W2334654004 hasConcept C521977710 @default.
- W2334654004 hasConcept C523546767 @default.
- W2334654004 hasConcept C54355233 @default.
- W2334654004 hasConcept C547475151 @default.