Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334656042> ?p ?o ?g. }
- W2334656042 endingPage "e59" @default.
- W2334656042 startingPage "e55" @default.
- W2334656042 abstract "Goals: To evaluate the significance of osteopontin (OPN) genotypes in the susceptibility to gastric cancer. Background: The expression of OPN has been correlated with development, invasiveness, metastasis, and survival of gastric cancer, but the role of polymorphisms in the OPN promoter has not been investigated. Study: We enrolled 146 gastric cancer patients and 128 controls. DNA was extracted from peripheral blood leucocytes. Single-nucleotide polymorphisms (SNPs) in the OPN promoter (−66, −156, −443, −616, −1748, and −1776) were analyzed by pyrosequencing and direct sequencing methods. Logistic regression analyses were used to evaluate the associations between SNPs and development of gastric cancer. Results: SNP −443 C/C and −616 T/T of the OPN promoter were significantly associated with gastric cancer [odds ratio (OR)=2.88; 95% confidence interval (CI), 1.16-7.12 and OR=1.95; 95% CI, 1.35-2.82, respectively]. Analysis of the combined effect of OPN promoter SNPs revealed that the combination of SNP −443 (T/C or C/C) and SNP −616 (T/T or T/G) had the most significant association with gastric cancer (OR=3.95; 95% CI, 1.58-9.90). Conclusions: Our results suggest that polymorphisms in the OPN promoter are associated with the development of gastric cancer, and the combination of SNP −443 (T/C or C/C) and −616 (T/T or T/G) most significantly increases susceptibility to gastric cancer." @default.
- W2334656042 created "2016-06-24" @default.
- W2334656042 creator A5002955708 @default.
- W2334656042 creator A5005317637 @default.
- W2334656042 creator A5012235577 @default.
- W2334656042 creator A5030056454 @default.
- W2334656042 creator A5040270289 @default.
- W2334656042 creator A5044827208 @default.
- W2334656042 creator A5048137173 @default.
- W2334656042 creator A5080353358 @default.
- W2334656042 date "2013-07-01" @default.
- W2334656042 modified "2023-10-18" @default.
- W2334656042 title "Osteopontin Promoter Polymorphisms are Associated With Susceptibility to Gastric Cancer" @default.
- W2334656042 cites W1586278659 @default.
- W2334656042 cites W1839374763 @default.
- W2334656042 cites W1945369727 @default.
- W2334656042 cites W1972711132 @default.
- W2334656042 cites W1977026479 @default.
- W2334656042 cites W1998369500 @default.
- W2334656042 cites W2005129602 @default.
- W2334656042 cites W2017353137 @default.
- W2334656042 cites W2019775182 @default.
- W2334656042 cites W2025474825 @default.
- W2334656042 cites W2025710239 @default.
- W2334656042 cites W2026699642 @default.
- W2334656042 cites W2036209209 @default.
- W2334656042 cites W2042758849 @default.
- W2334656042 cites W2044410462 @default.
- W2334656042 cites W2044756704 @default.
- W2334656042 cites W2055320560 @default.
- W2334656042 cites W2063539736 @default.
- W2334656042 cites W2069971929 @default.
- W2334656042 cites W2073950425 @default.
- W2334656042 cites W2092589546 @default.
- W2334656042 cites W2094858991 @default.
- W2334656042 cites W2096962515 @default.
- W2334656042 cites W2098097911 @default.
- W2334656042 cites W2099058664 @default.
- W2334656042 cites W2099973883 @default.
- W2334656042 cites W2107298306 @default.
- W2334656042 cites W2108081845 @default.
- W2334656042 cites W2116088042 @default.
- W2334656042 cites W2129442835 @default.
- W2334656042 cites W2139478219 @default.
- W2334656042 cites W2151969816 @default.
- W2334656042 cites W2162686939 @default.
- W2334656042 cites W2183219427 @default.
- W2334656042 cites W45643372 @default.
- W2334656042 doi "https://doi.org/10.1097/mcg.0b013e31827b9325" @default.
- W2334656042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23426449" @default.
- W2334656042 hasPublicationYear "2013" @default.
- W2334656042 type Work @default.
- W2334656042 sameAs 2334656042 @default.
- W2334656042 citedByCount "15" @default.
- W2334656042 countsByYear W23346560422014 @default.
- W2334656042 countsByYear W23346560422015 @default.
- W2334656042 countsByYear W23346560422016 @default.
- W2334656042 countsByYear W23346560422017 @default.
- W2334656042 countsByYear W23346560422018 @default.
- W2334656042 countsByYear W23346560422021 @default.
- W2334656042 countsByYear W23346560422023 @default.
- W2334656042 crossrefType "journal-article" @default.
- W2334656042 hasAuthorship W2334656042A5002955708 @default.
- W2334656042 hasAuthorship W2334656042A5005317637 @default.
- W2334656042 hasAuthorship W2334656042A5012235577 @default.
- W2334656042 hasAuthorship W2334656042A5030056454 @default.
- W2334656042 hasAuthorship W2334656042A5040270289 @default.
- W2334656042 hasAuthorship W2334656042A5044827208 @default.
- W2334656042 hasAuthorship W2334656042A5048137173 @default.
- W2334656042 hasAuthorship W2334656042A5080353358 @default.
- W2334656042 hasBestOaLocation W23346560422 @default.
- W2334656042 hasConcept C101762097 @default.
- W2334656042 hasConcept C104317684 @default.
- W2334656042 hasConcept C121608353 @default.
- W2334656042 hasConcept C126322002 @default.
- W2334656042 hasConcept C135763542 @default.
- W2334656042 hasConcept C139275648 @default.
- W2334656042 hasConcept C143998085 @default.
- W2334656042 hasConcept C150194340 @default.
- W2334656042 hasConcept C153209595 @default.
- W2334656042 hasConcept C156957248 @default.
- W2334656042 hasConcept C2779013556 @default.
- W2334656042 hasConcept C2780804394 @default.
- W2334656042 hasConcept C44249647 @default.
- W2334656042 hasConcept C54355233 @default.
- W2334656042 hasConcept C71924100 @default.
- W2334656042 hasConcept C86803240 @default.
- W2334656042 hasConcept C90924648 @default.
- W2334656042 hasConceptScore W2334656042C101762097 @default.
- W2334656042 hasConceptScore W2334656042C104317684 @default.
- W2334656042 hasConceptScore W2334656042C121608353 @default.
- W2334656042 hasConceptScore W2334656042C126322002 @default.
- W2334656042 hasConceptScore W2334656042C135763542 @default.
- W2334656042 hasConceptScore W2334656042C139275648 @default.
- W2334656042 hasConceptScore W2334656042C143998085 @default.
- W2334656042 hasConceptScore W2334656042C150194340 @default.
- W2334656042 hasConceptScore W2334656042C153209595 @default.
- W2334656042 hasConceptScore W2334656042C156957248 @default.