FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334667221> ?p ?o ?g. }

• W2334667221 endingPage "2047" @default.
• W2334667221 startingPage "2040" @default.
• W2334667221 abstract "Hypertriglyceridemia (HTG) is a common lipid abnormality in humans. However, its etiology remains largely unknown. It was shown that severe HTG can be induced in mice by overexpression of wild-type (WT) apolipoprotein E (apoE) or specific apoA-I mutants. Certain mutations in apoE4 were found to affect plasma triglyceride (TG) levels in mice overexpressing the protein. HTG appeared to positively correlate with the ability of the apoE4 variants to bind to TG-rich particles, protein destabilization, and the exposure of protein hydrophobic surface in solution. Here, we propose that the apoA-I mutations that cause HTG may also lead to changes in the conformation and stability that promote binding of apoA-I to TG-rich lipoproteins. To test this hypothesis, we studied binding to TG-rich emulsion and biophysical properties of the apoA-I mutants that induce HTG, apoA-I[E110A/E111A] and apoA-I[Δ(61-78)], and compared them to those of WT apoA-I and another apoA-I mutant, apoA-I[Δ(89-99)], that does not induce HTG but causes hypercholesterolemia in mice. We found that the apoA-I[E110A/E111A] and apoA-I[Δ(61-78)] mutations lead to enhanced binding of apoA-I to TG-rich particles, destabilization, and greater exposure of the hydrophobic surface of the protein. The apoA-I[Δ(89-99)] mutant did not show enhanced binding to the emulsion or a more exposed hydrophobic surface. Thus, like apoE4, the apoA-I variants that cause HTG in mice have the altered conformation and stability that facilitate their binding to TG-rich lipoproteins and thereby may lead to the reduced level of lipolysis of these lipoproteins. While many factors may be involved in induction of HTG, we suggest that an increased level of association of destabilized loosely folded apolipoproteins with TG-rich lipoproteins may contribute to some cases of HTG in humans." @default.
• W2334667221 created "2016-06-24" @default.
• W2334667221 creator A5024374500 @default.
• W2334667221 creator A5085977786 @default.
• W2334667221 date "2011-02-20" @default.
• W2334667221 modified "2023-09-27" @default.
• W2334667221 title "Enhanced Binding of Apolipoprotein A-I Variants Associated with Hypertriglyceridemia to Triglyceride-Rich Particles" @default.
• W2334667221 cites W1512176015 @default.
• W2334667221 cites W1513897103 @default.
• W2334667221 cites W1775749144 @default.
• W2334667221 cites W1887901770 @default.
• W2334667221 cites W1967374526 @default.
• W2334667221 cites W1971796665 @default.
• W2334667221 cites W1977311675 @default.
• W2334667221 cites W1977597405 @default.
• W2334667221 cites W1979390074 @default.
• W2334667221 cites W1992439290 @default.
• W2334667221 cites W1994211676 @default.
• W2334667221 cites W1994509415 @default.
• W2334667221 cites W1999498121 @default.
• W2334667221 cites W2002545455 @default.
• W2334667221 cites W2003508016 @default.
• W2334667221 cites W2003889403 @default.
• W2334667221 cites W2004137387 @default.
• W2334667221 cites W2006324786 @default.
• W2334667221 cites W2007819827 @default.
• W2334667221 cites W2016579573 @default.
• W2334667221 cites W2024271923 @default.
• W2334667221 cites W2036553241 @default.
• W2334667221 cites W2040068206 @default.
• W2334667221 cites W2044465436 @default.
• W2334667221 cites W2049314229 @default.
• W2334667221 cites W2052288531 @default.
• W2334667221 cites W2062228103 @default.
• W2334667221 cites W2062460068 @default.
• W2334667221 cites W2063174765 @default.
• W2334667221 cites W2079952421 @default.
• W2334667221 cites W2080826271 @default.
• W2334667221 cites W2080848089 @default.
• W2334667221 cites W2081850266 @default.
• W2334667221 cites W2093272247 @default.
• W2334667221 cites W2119882112 @default.
• W2334667221 cites W2145538573 @default.
• W2334667221 cites W2159786214 @default.
• W2334667221 cites W2325931377 @default.
• W2334667221 cites W4232807629 @default.
• W2334667221 doi "https://doi.org/10.1021/bi200158b" @default.
• W2334667221 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128146" @default.
• W2334667221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21288012" @default.
• W2334667221 hasPublicationYear "2011" @default.
• W2334667221 type Work @default.
• W2334667221 sameAs 2334667221 @default.
• W2334667221 citedByCount "7" @default.
• W2334667221 countsByYear W23346672212014 @default.
• W2334667221 countsByYear W23346672212017 @default.
• W2334667221 countsByYear W23346672212023 @default.
• W2334667221 crossrefType "journal-article" @default.
• W2334667221 hasAuthorship W2334667221A5024374500 @default.
• W2334667221 hasAuthorship W2334667221A5085977786 @default.
• W2334667221 hasBestOaLocation W23346672212 @default.
• W2334667221 hasConcept C104317684 @default.
• W2334667221 hasConcept C126322002 @default.
• W2334667221 hasConcept C143065580 @default.
• W2334667221 hasConcept C185592680 @default.
• W2334667221 hasConcept C2776919658 @default.
• W2334667221 hasConcept C2778163477 @default.
• W2334667221 hasConcept C2778913445 @default.
• W2334667221 hasConcept C2779134260 @default.
• W2334667221 hasConcept C55493867 @default.
• W2334667221 hasConcept C57089818 @default.
• W2334667221 hasConcept C62746215 @default.
• W2334667221 hasConcept C71924100 @default.
• W2334667221 hasConceptScore W2334667221C104317684 @default.
• W2334667221 hasConceptScore W2334667221C126322002 @default.
• W2334667221 hasConceptScore W2334667221C143065580 @default.
• W2334667221 hasConceptScore W2334667221C185592680 @default.
• W2334667221 hasConceptScore W2334667221C2776919658 @default.
• W2334667221 hasConceptScore W2334667221C2778163477 @default.
• W2334667221 hasConceptScore W2334667221C2778913445 @default.
• W2334667221 hasConceptScore W2334667221C2779134260 @default.
• W2334667221 hasConceptScore W2334667221C55493867 @default.
• W2334667221 hasConceptScore W2334667221C57089818 @default.
• W2334667221 hasConceptScore W2334667221C62746215 @default.
• W2334667221 hasConceptScore W2334667221C71924100 @default.
• W2334667221 hasIssue "12" @default.
• W2334667221 hasLocation W23346672211 @default.
• W2334667221 hasLocation W23346672212 @default.
• W2334667221 hasLocation W23346672213 @default.
• W2334667221 hasLocation W23346672214 @default.
• W2334667221 hasOpenAccess W2334667221 @default.
• W2334667221 hasPrimaryLocation W23346672211 @default.
• W2334667221 hasRelatedWork W2023192137 @default.
• W2334667221 hasRelatedWork W2034551870 @default.
• W2334667221 hasRelatedWork W2038144491 @default.
• W2334667221 hasRelatedWork W2084004255 @default.
• W2334667221 hasRelatedWork W2089747403 @default.
• W2334667221 hasRelatedWork W2092521864 @default.
• W2334667221 hasRelatedWork W2165961239 @default.

• next