FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334677746> ?p ?o ?g. }

• W2334677746 endingPage "1655" @default.
• W2334677746 startingPage "1646" @default.
• W2334677746 abstract "Macromolecular ruthenium complexes are a promising avenue to better, and more selective, chemotherapeutics. NAMI-A is a ruthenium(III) drug in Phase II clinical trials that has low cytotoxicity and is inactive against primary tumors. However, it displays both antiangiogenic and anti-invasive properties and has been shown to specifically target tumor metastases, preventing both development and growth. To increase the cytotoxicity and cell uptake of this promising drug, we designed a biocompatible amphiphilic block copolymer capable of self-assembling into polymeric micelles. An appropriate method for the synthesis of a macromolecular NAMI-A drug was identified—the polymerization of vinyl imidazole and subsequent addition of a ruthenium(III) precursor complex. The cytotoxicity of these polymeric moieties was tested on ovarian cancer A2780 and Ovcar-3 and pancreatic AsPC-1 cancer cell lines. On average, across the tested cell lines, a 1.5 times increase in toxicity was found for the NAMI-A copolymer micelles when compared to the NAMI-A molecule. Furthermore, the antimetastatic potential was assessed by evaluating the inhibitory effects on the migration and invasion of cells against three cell lines characterized by differing degrees of malignancy (MDA-MB-231 > MCF-7 > CHO). The NAMI-A micelles were shown to have an improved antimetastatic potential in comparison to NAMI-A." @default.
• W2334677746 created "2016-06-24" @default.
• W2334677746 creator A5005513668 @default.
• W2334677746 creator A5016059121 @default.
• W2334677746 creator A5030004307 @default.
• W2334677746 creator A5035379661 @default.
• W2334677746 date "2014-02-26" @default.
• W2334677746 modified "2023-10-01" @default.
• W2334677746 title "Superior Chemotherapeutic Benefits from the Ruthenium-Based Anti-Metastatic Drug NAMI-A through Conjugation to Polymeric Micelles" @default.
• W2334677746 cites W127176811 @default.
• W2334677746 cites W1965487870 @default.
• W2334677746 cites W1972459558 @default.
• W2334677746 cites W1978140867 @default.
• W2334677746 cites W1979266847 @default.
• W2334677746 cites W1984365115 @default.
• W2334677746 cites W1991458088 @default.
• W2334677746 cites W1994073437 @default.
• W2334677746 cites W1996987032 @default.
• W2334677746 cites W2000136129 @default.
• W2334677746 cites W2000584621 @default.
• W2334677746 cites W2001492916 @default.
• W2334677746 cites W2008239092 @default.
• W2334677746 cites W2019256848 @default.
• W2334677746 cites W2023868317 @default.
• W2334677746 cites W2024565349 @default.
• W2334677746 cites W2033160083 @default.
• W2334677746 cites W2035745723 @default.
• W2334677746 cites W2039979361 @default.
• W2334677746 cites W2047273860 @default.
• W2334677746 cites W2055321318 @default.
• W2334677746 cites W2061837827 @default.
• W2334677746 cites W2066825427 @default.
• W2334677746 cites W2071840467 @default.
• W2334677746 cites W2072596279 @default.
• W2334677746 cites W2074469414 @default.
• W2334677746 cites W2077612091 @default.
• W2334677746 cites W2078034063 @default.
• W2334677746 cites W2079864253 @default.
• W2334677746 cites W2093786230 @default.
• W2334677746 cites W2104174988 @default.
• W2334677746 cites W2121649359 @default.
• W2334677746 cites W2129213133 @default.
• W2334677746 cites W2134203244 @default.
• W2334677746 cites W2147450568 @default.
• W2334677746 cites W2152187896 @default.
• W2334677746 cites W2326096279 @default.
• W2334677746 cites W2333067472 @default.
• W2334677746 cites W3994596 @default.
• W2334677746 cites W4244811063 @default.
• W2334677746 doi "https://doi.org/10.1021/ma402078d" @default.
• W2334677746 hasPublicationYear "2014" @default.
• W2334677746 type Work @default.
• W2334677746 sameAs 2334677746 @default.
• W2334677746 citedByCount "39" @default.
• W2334677746 countsByYear W23346777462014 @default.
• W2334677746 countsByYear W23346777462015 @default.
• W2334677746 countsByYear W23346777462016 @default.
• W2334677746 countsByYear W23346777462017 @default.
• W2334677746 countsByYear W23346777462018 @default.
• W2334677746 countsByYear W23346777462019 @default.
• W2334677746 countsByYear W23346777462020 @default.
• W2334677746 countsByYear W23346777462021 @default.
• W2334677746 countsByYear W23346777462022 @default.
• W2334677746 countsByYear W23346777462023 @default.
• W2334677746 crossrefType "journal-article" @default.
• W2334677746 hasAuthorship W2334677746A5005513668 @default.
• W2334677746 hasAuthorship W2334677746A5016059121 @default.
• W2334677746 hasAuthorship W2334677746A5030004307 @default.
• W2334677746 hasAuthorship W2334677746A5035379661 @default.
• W2334677746 hasConcept C109316439 @default.
• W2334677746 hasConcept C11268172 @default.
• W2334677746 hasConcept C15920480 @default.
• W2334677746 hasConcept C161790260 @default.
• W2334677746 hasConcept C178790620 @default.
• W2334677746 hasConcept C184651966 @default.
• W2334677746 hasConcept C185592680 @default.
• W2334677746 hasConcept C202751555 @default.
• W2334677746 hasConcept C21951064 @default.
• W2334677746 hasConcept C2780035454 @default.
• W2334677746 hasConcept C521977710 @default.
• W2334677746 hasConcept C55493867 @default.
• W2334677746 hasConcept C555196967 @default.
• W2334677746 hasConcept C71924100 @default.
• W2334677746 hasConcept C98274493 @default.
• W2334677746 hasConceptScore W2334677746C109316439 @default.
• W2334677746 hasConceptScore W2334677746C11268172 @default.
• W2334677746 hasConceptScore W2334677746C15920480 @default.
• W2334677746 hasConceptScore W2334677746C161790260 @default.
• W2334677746 hasConceptScore W2334677746C178790620 @default.
• W2334677746 hasConceptScore W2334677746C184651966 @default.
• W2334677746 hasConceptScore W2334677746C185592680 @default.
• W2334677746 hasConceptScore W2334677746C202751555 @default.
• W2334677746 hasConceptScore W2334677746C21951064 @default.
• W2334677746 hasConceptScore W2334677746C2780035454 @default.
• W2334677746 hasConceptScore W2334677746C521977710 @default.
• W2334677746 hasConceptScore W2334677746C55493867 @default.
• W2334677746 hasConceptScore W2334677746C555196967 @default.
• W2334677746 hasConceptScore W2334677746C71924100 @default.

• next