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- W2334686263 abstract "The G-protein–coupled receptor 120 (GPR120) is a receptor for polyunsaturated fatty acids with anti-inflammatory activity. The R270H variant of GPR120 enhances inflammation in adipose and hepatic tissues. We investigated whether the R270H variant could play a role in determining liver injury in children and adolescents with obesity. Five hundred eighty-one children with obesity were studied. No homozygotes and 20 heterozygotes for the 270H allele were found. Heterozygotes showed higher alanine transaminase (ALT) levels (P = 0.01) than wild-type subjects, and also showed an odds ratio to have pathologic ALT of 3.2 (95% confidence interval [CI] 1.2–8.0, P < 0.05). Moreover, we genotyped the same patients for the patatin-like phospholipase-containing domain 3 (PNPLA3) I148M polymorphism, which is implicated in the development of liver steatosis. Stratifying the patients with the GPR120 270H variant on the basis of their PNPLA3 polymorphism, we demonstrated a significant interaction effect on ALT levels (P = 0.00001), suggesting a driving effect of the PNPLA3 148M allele on liver injury in children with obesity carrying this variant." @default.
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- W2334686263 date "2014-10-01" @default.
- W2334686263 modified "2023-10-18" @default.
- W2334686263 title "Novel Association Between a Nonsynonymous Variant (R270H) of the G-Protein–Coupled Receptor 120 and Liver Injury in Children and Adolescents With Obesity" @default.
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- W2334686263 doi "https://doi.org/10.1097/mpg.0000000000000463" @default.
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