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- W2334689478 abstract "Objective : This study investigated the inflammatory reaction is characterized by over production of inflammatory mediators due to an up-regulation of inflammatory pathways.Methods : We investigated the anti-inflammatory effects of water extracts fromLonicera japonicaandScutellaria baicalensisin lipopolysaccharide (LPS)-stimulated U937 cells. Each extract suppressed the production of inflammatory mediators (NO, IL-1<TEX>${beta}$</TEX>, TNF-<TEX>${beta}$</TEX>, and PGE<sub>2</sub>) and the expression of inducible NO synthase and cyclooxygenase-2 in LPS- stimulated U937 cells in a dose-dependent manner.Results : These suggest that the suppression effects were synergistically increased by their combination. Their combination extract also inhibited NF-<TEX>${kappa}B$</TEX>-DNA complex of NF-<TEX>${kappa}B$</TEX> binding activity and translocation of NF-<TEX>${kappa}B$</TEX> from cytosol to nucleus.Conclusions : Our study suggest that the combination of water-extractable components ofL. japonicaandS. baicalensismay be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators." @default.
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- W2334689478 date "2015-08-25" @default.
- W2334689478 modified "2023-09-26" @default.
- W2334689478 title "Study on the Anti-inflammatory Effects of the Remedy Prescripted with Lonicera japonica and Scutellaria baicalensis Radix in U937 cells" @default.
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- W2334689478 doi "https://doi.org/10.6114/jkood.2015.28.3.001" @default.
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