Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334694428> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2334694428 endingPage "778" @default.
- W2334694428 startingPage "773" @default.
- W2334694428 abstract "To investigate the mechanism of the hypergastrinaemia associated with Helicobacter pylori infection by examining the effect of H. pylori infection and the cytokine tumour necrosis factor-alpha (TNF-alpha) on gastrin release from human antral fragments.In-vitro experimental study.Human antral biopsy fragments were cultured for 6 h with and without TNF-alpha (20 ng/ml) and the gastrin released over the following 2-h stimulation period measured by radioimmunoassay. The integrity of the paracrine feedback loop inhibiting gastrin release was tested by concurrent administration of cholecystokinin (CCK).H. pylori-positive fragments were associated with significantly greater bombesin-stimulated gastrin release (increased by 40%, P < 0.05) and less inhibition produced by CCK administration (decreased by 55%, P < 0.05), than H. pylori-negative fragments. TNF-alpha treatment of H. pylori-negative fragments significantly enhanced bombesin-stimulated gastrin release (by 82%, P < 0.01) and diminished inhibitory feedback by CCK (by 53%, P < 0.05).H. pylori infection is associated with enhanced gastrin release from human antrum and TNF-alpha produces a similar effect. Proinflammatory cytokines generated in the antrum in response to the infection are likely to play a significant role in the hypergastrinaemia of H. pylori infection." @default.
- W2334694428 created "2016-06-24" @default.
- W2334694428 creator A5009689476 @default.
- W2334694428 creator A5081812524 @default.
- W2334694428 date "1997-08-01" @default.
- W2334694428 modified "2023-09-26" @default.
- W2334694428 title "Helicobacter pylori infection and tumour necrosis factor-α increase gastrin release from human gastric antral fragments" @default.
- W2334694428 doi "https://doi.org/10.1097/00042737-199708000-00007" @default.
- W2334694428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9282274" @default.
- W2334694428 hasPublicationYear "1997" @default.
- W2334694428 type Work @default.
- W2334694428 sameAs 2334694428 @default.
- W2334694428 citedByCount "27" @default.
- W2334694428 countsByYear W23346944282013 @default.
- W2334694428 countsByYear W23346944282021 @default.
- W2334694428 crossrefType "journal-article" @default.
- W2334694428 hasAuthorship W2334694428A5009689476 @default.
- W2334694428 hasAuthorship W2334694428A5081812524 @default.
- W2334694428 hasConcept C118303440 @default.
- W2334694428 hasConcept C119811328 @default.
- W2334694428 hasConcept C126322002 @default.
- W2334694428 hasConcept C131253125 @default.
- W2334694428 hasConcept C134018914 @default.
- W2334694428 hasConcept C164027704 @default.
- W2334694428 hasConcept C170493617 @default.
- W2334694428 hasConcept C176685330 @default.
- W2334694428 hasConcept C17991360 @default.
- W2334694428 hasConcept C24998067 @default.
- W2334694428 hasConcept C2776409635 @default.
- W2334694428 hasConcept C2776914184 @default.
- W2334694428 hasConcept C2776986829 @default.
- W2334694428 hasConcept C2777593968 @default.
- W2334694428 hasConcept C2777951760 @default.
- W2334694428 hasConcept C2778448772 @default.
- W2334694428 hasConcept C2779422922 @default.
- W2334694428 hasConcept C2910480513 @default.
- W2334694428 hasConcept C49039625 @default.
- W2334694428 hasConcept C56191518 @default.
- W2334694428 hasConcept C71315377 @default.
- W2334694428 hasConcept C71924100 @default.
- W2334694428 hasConceptScore W2334694428C118303440 @default.
- W2334694428 hasConceptScore W2334694428C119811328 @default.
- W2334694428 hasConceptScore W2334694428C126322002 @default.
- W2334694428 hasConceptScore W2334694428C131253125 @default.
- W2334694428 hasConceptScore W2334694428C134018914 @default.
- W2334694428 hasConceptScore W2334694428C164027704 @default.
- W2334694428 hasConceptScore W2334694428C170493617 @default.
- W2334694428 hasConceptScore W2334694428C176685330 @default.
- W2334694428 hasConceptScore W2334694428C17991360 @default.
- W2334694428 hasConceptScore W2334694428C24998067 @default.
- W2334694428 hasConceptScore W2334694428C2776409635 @default.
- W2334694428 hasConceptScore W2334694428C2776914184 @default.
- W2334694428 hasConceptScore W2334694428C2776986829 @default.
- W2334694428 hasConceptScore W2334694428C2777593968 @default.
- W2334694428 hasConceptScore W2334694428C2777951760 @default.
- W2334694428 hasConceptScore W2334694428C2778448772 @default.
- W2334694428 hasConceptScore W2334694428C2779422922 @default.
- W2334694428 hasConceptScore W2334694428C2910480513 @default.
- W2334694428 hasConceptScore W2334694428C49039625 @default.
- W2334694428 hasConceptScore W2334694428C56191518 @default.
- W2334694428 hasConceptScore W2334694428C71315377 @default.
- W2334694428 hasConceptScore W2334694428C71924100 @default.
- W2334694428 hasIssue "8" @default.
- W2334694428 hasLocation W23346944281 @default.
- W2334694428 hasLocation W23346944282 @default.
- W2334694428 hasOpenAccess W2334694428 @default.
- W2334694428 hasPrimaryLocation W23346944281 @default.
- W2334694428 hasRelatedWork W130637186 @default.
- W2334694428 hasRelatedWork W13786586 @default.
- W2334694428 hasRelatedWork W1838444809 @default.
- W2334694428 hasRelatedWork W2026058879 @default.
- W2334694428 hasRelatedWork W2040889934 @default.
- W2334694428 hasRelatedWork W2069633620 @default.
- W2334694428 hasRelatedWork W2086389855 @default.
- W2334694428 hasRelatedWork W2334694428 @default.
- W2334694428 hasRelatedWork W2399713751 @default.
- W2334694428 hasRelatedWork W2402076111 @default.
- W2334694428 hasVolume "9" @default.
- W2334694428 isParatext "false" @default.
- W2334694428 isRetracted "false" @default.
- W2334694428 magId "2334694428" @default.
- W2334694428 workType "article" @default.