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- W2334701468 abstract "Scutellarin (1) possesses distinguished efficacy in the clinical therapy of cerebral infarction, coronary heart disease, and angina pectoris. Scutellarin (1) is readily converted in vivo, therefore, synthetic methods for the construction of its metabolites will be very important in the near future. In this work, an efficient and first synthetic method for 6-O-methyl- scutellarein (3), one metabolite of scutellarin in vivo, is developed. Dichlorodiphenylmethane in diphenyl ether is used firstly to protect the dihydroxy groups at C-6 and C-7 in scutellarein (2). Then, benzyl bromide is used to selectively protect the hydroxy groups at C-4' and C-7 in 10. 6-O-Methyl-scutellarein (3) is obtained in high yield through seven steps. Keywords: 6-O-methyl-scutellarein, metabolite, scutellarin, synthesis, regioselective protection." @default.
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- W2334701468 date "2013-11-01" @default.
- W2334701468 modified "2023-10-16" @default.
- W2334701468 title "Efficient Synthesis of 6-O-methyl-scutellarein from Scutellarin via Selective Methylation" @default.
- W2334701468 doi "https://doi.org/10.2174/15701786113109990046" @default.
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