FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334703071> ?p ?o ?g. }

• W2334703071 endingPage "2821" @default.
• W2334703071 startingPage "2814" @default.
• W2334703071 abstract "In situ forming hydrogels were developed from 4-arm poly(ethylene glycol)–methacrylate (PEG-4-MA) and −tetrazole (PEG-4-Tet) derivatives through catalyst-free and bioorthogonal “tetrazole–alkene” photo-click chemistry. PEG-4-MA and PEG-4-Tet (Mn = 10 kg/mol) were soluble at 37 °C in phosphate buffer (PB, pH 7.4, 10 mM) at total polymer concentrations ranging from 20 to 60 wt % but formed fluorescent hydrogels upon 365 nm UV irradiation at an intensity of 20.6, 30.7, or 60 mW/cm2. The gelation times ranged from ca. 50 s to 5 min, and storage moduli varied from 0.65 to 25.2 kPa depending on polymer concentrations and degrees of Tet substitution in PEG-4-Tet conjugates. The cell experiments via an indirect contact assay demonstrated that these “tetrazole–alkene” photo-click PEG hydrogels were noncytotoxic. The high specificity of photo-click reaction renders thus obtained PEG hydrogels particularly interesting for controlled protein release. Notably, in vitro release studies showed that cytochrome c (CC), γ-globulins (Ig), and recombinant human interleukin-2 (rhIL-2) all were released from PEG hydrogels in a sustained and quantitative manner over a period of 14–20 days. Importantly, released CC and rhIL-2 exhibited comparable biological activities to native CC and rhIL-2, respectively. These results confirm that “tetrazole–alkene” photo-click reaction is highly compatible with these loaded proteins. This photo-controlled, specific, efficient, and catalyst-free click chemistry provides a new and versatile strategy to in situ forming hydrogels that hold tremendous potentials for protein delivery and tissue engineering." @default.
• W2334703071 created "2016-06-24" @default.
• W2334703071 creator A5026189929 @default.
• W2334703071 creator A5027783150 @default.
• W2334703071 creator A5039037778 @default.
• W2334703071 creator A5067189270 @default.
• W2334703071 creator A5077781605 @default.
• W2334703071 date "2013-07-12" @default.
• W2334703071 modified "2023-10-18" @default.
• W2334703071 title "<i>In Situ</i> Forming Hydrogels via Catalyst-Free and Bioorthogonal “Tetrazole–Alkene” Photo-Click Chemistry" @default.
• W2334703071 cites W1963773424 @default.
• W2334703071 cites W1966819685 @default.
• W2334703071 cites W1966903068 @default.
• W2334703071 cites W1976971565 @default.
• W2334703071 cites W1981012071 @default.
• W2334703071 cites W1994032158 @default.
• W2334703071 cites W1994502455 @default.
• W2334703071 cites W1996720815 @default.
• W2334703071 cites W2001909877 @default.
• W2334703071 cites W2002968331 @default.
• W2334703071 cites W2005333067 @default.
• W2334703071 cites W2011312171 @default.
• W2334703071 cites W2018282847 @default.
• W2334703071 cites W2021552233 @default.
• W2334703071 cites W2024515148 @default.
• W2334703071 cites W2030557341 @default.
• W2334703071 cites W2031525159 @default.
• W2334703071 cites W2032306620 @default.
• W2334703071 cites W2033518295 @default.
• W2334703071 cites W2041117108 @default.
• W2334703071 cites W2052239784 @default.
• W2334703071 cites W2053625593 @default.
• W2334703071 cites W2054749836 @default.
• W2334703071 cites W2056240372 @default.
• W2334703071 cites W2058051209 @default.
• W2334703071 cites W2058310958 @default.
• W2334703071 cites W2058477557 @default.
• W2334703071 cites W2060226476 @default.
• W2334703071 cites W2060449729 @default.
• W2334703071 cites W2060835907 @default.
• W2334703071 cites W2067897176 @default.
• W2334703071 cites W2070170630 @default.
• W2334703071 cites W2073053027 @default.
• W2334703071 cites W2075121572 @default.
• W2334703071 cites W2075511023 @default.
• W2334703071 cites W2079081892 @default.
• W2334703071 cites W2081318971 @default.
• W2334703071 cites W2082182581 @default.
• W2334703071 cites W2082848755 @default.
• W2334703071 cites W2083276839 @default.
• W2334703071 cites W2086032244 @default.
• W2334703071 cites W2086608111 @default.
• W2334703071 cites W2087210228 @default.
• W2334703071 cites W2087526456 @default.
• W2334703071 cites W2088852132 @default.
• W2334703071 cites W2089023014 @default.
• W2334703071 cites W2094373630 @default.
• W2334703071 cites W2096943572 @default.
• W2334703071 cites W2109351872 @default.
• W2334703071 cites W2111733899 @default.
• W2334703071 cites W2117940877 @default.
• W2334703071 cites W2135880302 @default.
• W2334703071 cites W2144546863 @default.
• W2334703071 cites W2163632301 @default.
• W2334703071 cites W2307078552 @default.
• W2334703071 cites W2317707654 @default.
• W2334703071 cites W2415067039 @default.
• W2334703071 cites W4233602835 @default.
• W2334703071 cites W4298373351 @default.
• W2334703071 doi "https://doi.org/10.1021/bm400637s" @default.
• W2334703071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23819863" @default.
• W2334703071 hasPublicationYear "2013" @default.
• W2334703071 type Work @default.
• W2334703071 sameAs 2334703071 @default.
• W2334703071 citedByCount "78" @default.
• W2334703071 countsByYear W23347030712013 @default.
• W2334703071 countsByYear W23347030712014 @default.
• W2334703071 countsByYear W23347030712015 @default.
• W2334703071 countsByYear W23347030712016 @default.
• W2334703071 countsByYear W23347030712017 @default.
• W2334703071 countsByYear W23347030712018 @default.
• W2334703071 countsByYear W23347030712019 @default.
• W2334703071 countsByYear W23347030712020 @default.
• W2334703071 countsByYear W23347030712021 @default.
• W2334703071 countsByYear W23347030712022 @default.
• W2334703071 countsByYear W23347030712023 @default.
• W2334703071 crossrefType "journal-article" @default.
• W2334703071 hasAuthorship W2334703071A5026189929 @default.
• W2334703071 hasAuthorship W2334703071A5027783150 @default.
• W2334703071 hasAuthorship W2334703071A5039037778 @default.
• W2334703071 hasAuthorship W2334703071A5067189270 @default.
• W2334703071 hasAuthorship W2334703071A5077781605 @default.
• W2334703071 hasConcept C10138342 @default.
• W2334703071 hasConcept C108586683 @default.
• W2334703071 hasConcept C13965031 @default.
• W2334703071 hasConcept C161790260 @default.
• W2334703071 hasConcept C162324750 @default.
• W2334703071 hasConcept C178790620 @default.

• next