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• W2334727412 abstract "Closantel(N-[5-chloro-4[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]-2-hydroxy3,5,diiodobenzamide), a new, salicylanilide anthelmintic discovered at Janssen Pharmaceutica, Beerse, Belgium, by Janssen and Sipido (1977, U.S. Patent No. 4,005,218) has been found to have lethal activity against several species of nematodes, trematodes and arthropods (Van den Bossche et al., 1979, Arch. Int. de Physiol. et de Biochim. 87: 851-852; Guerrero et al., 1983, Vet. Parasit. 12: 71-77). Efficacy against adult and larval stages of Fasciola hepatica and F. gigantica has been previously demonstrated and the information summarized (Guerrero, 1983, Prev. Vet. Med. In Press); closantel seems to be especially effective against parasites which are either in close contact with circulating blood or that are hematophagus (Guerrero et al., 1982, J. Parasit. 68: 616-619). The present study was undertaken to determine if Closantel was effective in killing larvae of Fascioloides magna in sheep, a major economic problem in Minnesota and several other states in the USA. Twelve sheep (ewes) less than 12 mo old, mean weight of 38.7 kg, were purchased from a farm in an area known not to have liver flukes. It was believed that animals this age and size accurately reflect the age and size at which sheep on pasture would naturally be exposed to and become infected with F. magna for the first time. Sheep were maintained in indoor pens and held for 4 wk prior to infection. The sheep were fed a balanced ration of hay and concentrate throughout the experiment and received water ad lib. During this time fecal examinations were performed on all sheep on arrival and they were treated with thiabendazole, 50 mg/kg (Omnizole, Merck). Two weeks later fecal examinations were performed and some were still found to be positive for helminths. All animals were treated with levamisole at a dose of 8 mg/kg (Levasole, Pitman-Moore, Inc.). All animals were found to be negative for intestinal helminths at the start of the experiment." @default.
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• W2334727412 date "1984-06-01" @default.
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• W2334727412 title "The Efficacy of Closantel against Fascioloides magna in Sheep" @default.
• W2334727412 doi "https://doi.org/10.2307/3281582" @default.
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