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- W2334770921 abstract "Infl ammasomes are multiprotein complexes that serve as a platform for caspase-1 activation and interleukin-1β (IL- 1β) maturation as well as pyroptosis. Though a number of infl ammasomes have been described, the NLRP3 infl am- masome is the most extensively studied. NLRP3 infl am- masome is triggered by a variety of stimuli, including in- fection, tissue damage and metabolic dysregulation, and then activated through an integrated cellular signal. Many regulatory mechanisms have been identifi ed to attenuate NLRP3 infl ammasome signaling at multiple steps. Here, we review the developments in the negative regulation of NLRP3 inflammasome that protect host from inflamma- tory damage." @default.
- W2334770921 created "2016-06-24" @default.
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- W2334770921 date "2013-01-01" @default.
- W2334770921 modified "2023-09-27" @default.
- W2334770921 title "Negative regulation of NLRP3 infl ammasome signaling INI-REVIEW M" @default.
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