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- W2334787577 abstract "Interstitial cystitis/painful bladder syndrome (IC/PBS) is a severely debilitating condition that is frequently unresponsive to conventional pain medications and for which the etiology is unknown. In a variety of chronic pain conditions, CNS plasticity of glutamatergic signaling involving NMDA and metabotropic glutamate receptors has been implicated. Here, we test the hypothesis that metabotropic glutamate receptor 5 (mGluR5) mediates bladder nociception in the mouse by monitoring the visceromotor response (VMR) during graded bladder distention. Using a combination of genetic and pharmacologic studies, we provide data supporting the hypothesis that mGluR5 is necessary for the full expression of bladder pain. Anatomically targeted genetic, pharmacologic, and optogenetic studies were used to identify key anatomical loci of mGluR5 activation leading to bladder pain. Interstitial cystitis/painful bladder syndrome (IC/PBS) is a severely debilitating condition that is frequently unresponsive to conventional pain medications and for which the etiology is unknown. In a variety of chronic pain conditions, CNS plasticity of glutamatergic signaling involving NMDA and metabotropic glutamate receptors has been implicated. Here, we test the hypothesis that metabotropic glutamate receptor 5 (mGluR5) mediates bladder nociception in the mouse by monitoring the visceromotor response (VMR) during graded bladder distention. Using a combination of genetic and pharmacologic studies, we provide data supporting the hypothesis that mGluR5 is necessary for the full expression of bladder pain. Anatomically targeted genetic, pharmacologic, and optogenetic studies were used to identify key anatomical loci of mGluR5 activation leading to bladder pain." @default.
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- W2334787577 date "2012-04-01" @default.
- W2334787577 modified "2023-09-23" @default.
- W2334787577 title "Role of mGluR5 in bladder pain" @default.
- W2334787577 doi "https://doi.org/10.1016/j.jpain.2012.01.239" @default.
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